Baldwin D S, Neugarten J
Am J Kidney Dis. 1987 Sep;10(3):186-91. doi: 10.1016/s0272-6386(87)80173-7.
Experimental data are summarized that provide evidence that enhanced transmission of systemic hypertension to the glomerulus occurs in the setting of reduced renal mass. It is proposed that similar adaptive glomerular hemodynamic alterations occur in parenchymal renal disease in humans, favoring the development of intraorgan hypertension. Accelerated vascular and glomerular damage and functional deterioration result. Treatment of systemic hypertension with agents that reduce glomerular capillary pressure has been shown to ameliorate the manifestations of experimental glomerular disease. The importance of preventing hemodynamic injury to the arterioles and glomerular capillaries in the management of human renal disease is stressed.
实验数据总结如下，这些数据提供了证据，表明在肾实质减少的情况下，系统性高血压向肾小球的传递增强。有人提出，人类实质性肾脏疾病中也会出现类似的适应性肾小球血流动力学改变，这有利于器官内高血压的发展。进而导致血管和肾小球损伤加速以及功能恶化。已证明用降低肾小球毛细血管压力的药物治疗系统性高血压可改善实验性肾小球疾病的表现。强调了在人类肾脏疾病管理中预防对小动脉和肾小球毛细血管的血流动力学损伤的重要性。
