Calabrese J R, Kling M A, Gold P W
Am J Psychiatry. 1987 Sep;144(9):1123-34. doi: 10.1176/ajp.144.9.1123.
There is now clear evidence that stress, bereavement, and depression can compromise specific components of the immunologic apparatus. The first part of this paper gives an overview of fundamental immunology and is followed by a review of the patterns, possible causes, and potential clinical implications of abnormal immunoregulation. After a discussion of the immunomodulating properties of glucocorticoids, the authors conclude with an overview of the many factors that mediate the complex interdependence between immunologic function, the brain, and neuroendocrine regulation.
现在有明确的证据表明，压力、丧亲之痛和抑郁会损害免疫系统的特定组成部分。本文的第一部分概述了基础免疫学，随后回顾了免疫调节异常的模式、可能原因及潜在临床意义。在讨论了糖皮质激素的免疫调节特性后，作者最后概述了介导免疫功能、大脑和神经内分泌调节之间复杂相互依存关系的诸多因素。
