• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Patient-Specific Induced Pluripotent Stem Cells Implicate Intrinsic Impaired Contractility in Hypoplastic Left Heart Syndrome.患者特异性诱导多能干细胞揭示了左心发育不全综合征中内在的收缩功能受损。
Circulation. 2020 Oct 20;142(16):1605-1608. doi: 10.1161/CIRCULATIONAHA.119.045317. Epub 2020 Oct 19.
2
An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes.左心发育不全综合征(HLHS)的诱导多能干细胞模型揭示了 HLHS 来源的心肌细胞在多个表达和功能上的差异。
Stem Cells Transl Med. 2014 Apr;3(4):416-23. doi: 10.5966/sctm.2013-0105. Epub 2014 Mar 3.
3
Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency.NOTCH1 缺陷导致的人类心脏细胞发育障碍。
Circ Res. 2023 Jan 20;132(2):187-204. doi: 10.1161/CIRCRESAHA.122.321398. Epub 2022 Dec 30.
4
NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis.通过生物工程心脏发生中检测到的患者特异性表型揭示的左心发育不全综合征中NOTCH1依赖性一氧化氮信号缺陷
Stem Cells. 2017 Apr;35(4):1106-1119. doi: 10.1002/stem.2582. Epub 2017 Mar 5.
5
Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome.患者特异性诱导多能干细胞的定向分化确定了左心发育不全综合征中NKX2-5、HAND1和NOTCH1的转录抑制和表观遗传修饰。
PLoS One. 2014 Jul 22;9(7):e102796. doi: 10.1371/journal.pone.0102796. eCollection 2014.
6
Impact of MYH6 variants in hypoplastic left heart syndrome.MYH6 变异对左心发育不全综合征的影响。
Physiol Genomics. 2016 Dec 1;48(12):912-921. doi: 10.1152/physiolgenomics.00091.2016. Epub 2016 Oct 27.
7
Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial.经冠状动脉内自体心脏祖细胞移植治疗左心发育不良综合征患者:TICAP 前瞻性 1 期对照试验。
Circ Res. 2015 Feb 13;116(4):653-64. doi: 10.1161/CIRCRESAHA.116.304671. Epub 2014 Nov 17.
8
Single-Cell Transcriptomics of Engineered Cardiac Tissues From Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome.从患者特异性诱导多能干细胞衍生的心肌细胞构建的工程化心脏组织的单细胞转录组学揭示了右心发育不全综合征中的异常发育轨迹和内在收缩缺陷。
J Am Heart Assoc. 2020 Oct 20;9(20):e016528. doi: 10.1161/JAHA.120.016528. Epub 2020 Oct 16.
9
Fetal reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation.左心发育不全综合征中的胎儿重编程和衰老与人类多能干细胞在心脏分化过程中的衰老。
Am J Pathol. 2013 Sep;183(3):720-34. doi: 10.1016/j.ajpath.2013.05.022. Epub 2013 Jul 17.
10
Hypoplastic left heart syndrome: new insights.左心发育不全综合征:新见解
Circ Res. 2007 May 11;100(9):1246-8. doi: 10.1161/01.RES.0000268192.20525.c2.

引用本文的文献

1
Transformative Potential of Induced Pluripotent Stem Cells in Congenital Heart Disease Research and Treatment.诱导多能干细胞在先天性心脏病研究与治疗中的变革潜力。
Children (Basel). 2025 May 23;12(6):669. doi: 10.3390/children12060669.
2
The ERBB2 c.1795C>T, p.Arg599Cys variant is associated with left ventricular outflow tract obstruction defects in humans.ERBB2基因c.1795C>T、p.Arg599Cys变异与人类左心室流出道梗阻缺陷相关。
HGG Adv. 2025 Jul 10;6(3):100446. doi: 10.1016/j.xhgg.2025.100446. Epub 2025 May 5.
3
Current and future diagnostics of congenital heart disease (CHD).先天性心脏病(CHD)的当前及未来诊断方法
Med Genet. 2025 Apr 8;37(2):95-102. doi: 10.1515/medgen-2025-2008. eCollection 2025 Jun.
4
Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects.多能干细胞源性心肌细胞的成熟:代谢方面的局限性和挑战。
Stem Cell Res Ther. 2024 Oct 8;15(1):354. doi: 10.1186/s13287-024-03961-4.
5
In Vivo and In Vitro Approaches to Modeling Hypoplastic Left Heart Syndrome.体内和体外建模左心发育不全综合征的方法。
Curr Cardiol Rep. 2024 Nov;26(11):1221-1229. doi: 10.1007/s11886-024-02122-6. Epub 2024 Sep 28.
6
iPSC-Derived Cardiomyocytes as a Disease Model to Understand the Biology of Congenital Heart Defects.诱导多能干细胞衍生的心肌细胞作为疾病模型用于理解先天性心脏缺陷的生物学。
Cells. 2024 Aug 26;13(17):1430. doi: 10.3390/cells13171430.
7
The sum of the parts is greater than the whole: current research models for congenital heart disease.部分之和大于整体:先天性心脏病的当前研究模型
Nat Cardiovasc Res. 2023 Aug;2(8):708-710. doi: 10.1038/s44161-023-00308-9.
8
Current genetic models for studying congenital heart diseases: Advantages and disadvantages.当前用于研究先天性心脏病的遗传模型:优点与缺点。
Bioinformation. 2024 May 31;20(5):415-429. doi: 10.6026/973206300200415. eCollection 2024.
9
Applications of Single-Cell Omics Technologies for Induced Pluripotent Stem Cell-Based Cardiovascular Research.单细胞组学技术在基于诱导多能干细胞的心血管研究中的应用
Int J Stem Cells. 2025 Feb 28;18(1):37-48. doi: 10.15283/ijsc23183. Epub 2024 Aug 12.
10
Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity.线粒体 MICOS 复合物基因与左心发育不全综合征有关,可维持心肌收缩力和肌动球蛋白的完整性。
Elife. 2023 Jul 5;12:e83385. doi: 10.7554/eLife.83385.

本文引用的文献

1
Simple Lithography-Free Single Cell Micropatterning using Laser-Cut Stencils.使用激光切割模板实现简单的无光刻单细胞微图案化
J Vis Exp. 2020 Apr 3(158). doi: 10.3791/60888.
2
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.病理性基因网络重排提示 PPP1R3A 是压力超负荷性心力衰竭的中央调节因子。
Nat Commun. 2019 Jun 24;10(1):2760. doi: 10.1038/s41467-019-10591-5.
3
Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development.单细胞表达分析揭示了心脏发育过程中解剖结构和细胞周期依赖性的转录变化。
Development. 2019 Jun 14;146(12):dev173476. doi: 10.1242/dev.173476.
4
The complex genetics of hypoplastic left heart syndrome.左心发育不全综合征的复杂遗传学
Nat Genet. 2017 Jul;49(7):1152-1159. doi: 10.1038/ng.3870. Epub 2017 May 22.
5
NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis.通过生物工程心脏发生中检测到的患者特异性表型揭示的左心发育不全综合征中NOTCH1依赖性一氧化氮信号缺陷
Stem Cells. 2017 Apr;35(4):1106-1119. doi: 10.1002/stem.2582. Epub 2017 Mar 5.

Patient-Specific Induced Pluripotent Stem Cells Implicate Intrinsic Impaired Contractility in Hypoplastic Left Heart Syndrome.

作者信息

Paige Sharon L, Galdos Francisco X, Lee Soah, Chin Elizabeth T, Ranjbarvaziri Sara, Feyen Dries A M, Darsha Adrija K, Xu Sidra, Ryan Julia A, Beck Aimee L, Qureshi M Yasir, Miao Yifei, Gu Mingxia, Bernstein Daniel, Nelson Timothy J, Mercola Mark, Rabinovitch Marlene, Ashley Euan A, Parikh Victoria N, Wu Sean M

机构信息

Department of Pediatrics, Division of Pediatric Cardiology (S.L.P., S.R., J.A.R., Y.M., M.G., D.B., M.R., S.M.W.), Stanford School of Medicine, CA.

Cardiovascular Institute (S.L.P., E.T.C., F.X.G., S.L., S.R., D.A.M.F., A.K.D., S.X., J.A.R., A.L.B., Y.M., M.G., D.B., M.M., M.R., E.A.A., V.N.P., S.M.W.), Stanford School of Medicine, CA.

出版信息

Circulation. 2020 Oct 20;142(16):1605-1608. doi: 10.1161/CIRCULATIONAHA.119.045317. Epub 2020 Oct 19.

DOI:10.1161/CIRCULATIONAHA.119.045317
PMID:33074758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7583658/
Abstract
摘要