分子磁共振对比剂
Molecular MR Contrast Agents.
机构信息
From the Institute for Innovation in Imaging, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.
出版信息
Invest Radiol. 2021 Jan;56(1):20-34. doi: 10.1097/RLI.0000000000000731.
Molecular magnetic resonance (MR) imaging utilizes molecular probes to provide added biochemical or cellular information to what can already be achieved with anatomical and functional MR imaging. This review provides an overview of molecular MR and focuses specifically on molecular MR contrast agents that provide contrast by shortening the T1 time. We describe the requirements for a successful molecular MR contrast agent and the challenges for clinical translation. The review highlights work from the last 5 years and places an emphasis on new contrast agents that have been validated in multiple preclinical models. Applications of molecular MR include imaging of inflammation, fibrosis, fibrogenesis, thromboembolic disease, and cancers. Molecular MR is positioned to move beyond detection of disease to the quantitative staging of disease and measurement of treatment response.
分子磁共振成像（MR）利用分子探针，在已有的解剖和功能磁共振成像基础上，提供更多的生化或细胞信息。本综述概述了分子磁共振成像，并特别关注通过缩短 T1 时间提供对比的分子磁共振对比剂。我们描述了成功的分子磁共振对比剂的要求以及临床转化的挑战。该综述强调了过去 5 年的工作，并重点介绍了已在多个临床前模型中得到验证的新型对比剂。分子磁共振成像的应用包括炎症、纤维化、纤维生成、血栓栓塞性疾病和癌症的成像。分子磁共振成像有望超越疾病的检测，实现疾病的定量分期和治疗反应的测量。
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