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稀土元素在双模态分子探针中的应用。

Application of rare earth elements in dual-modality molecular probes.

作者信息

He Jie-Fang, Yang Wen-Wen, Quan Wen-Xuan, Yang Yue-Chun, Zhang Zhengwei, Luo Qing-Ying

机构信息

School of Life Sciences, Guizhou Normal University Guiyang 550025 China.

School of Food and Drug, Shenzhen Polytechnic University Shenzhen 518055 China

出版信息

RSC Adv. 2024 Dec 5;14(52):38480-38490. doi: 10.1039/d4ra04987j. eCollection 2024 Dec 3.

DOI:10.1039/d4ra04987j
PMID:39640527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11618533/
Abstract

The unique 4f subshell electronic structure of rare earth elements endows them with exceptional properties in electrical, magnetic, and optical domains. These properties include prolonged fluorescence lifetimes, large Stokes shifts, distinctive spectral bands, and strong resistance to photobleaching, making them ideal for the synthesis of molecular probes. Each imaging technique possesses unique advantages and specific applicabilities but also inherent limitations due to its operational principles. Dual-modality molecular probes effectively address these limitations, particularly in applications involving high-resolution Magnetic Resonance Imaging (MRI) such as MRI/OI, MRI/PET, MRI/CT, and MRI/US. This review summarizes the applications, advantages, challenges, and current research status of rare earth elements in these four dual imaging modalities, providing a theoretical basis for the future development and application of rare earth elements in the field of dual-modality molecular probes.

摘要

稀土元素独特的4f亚壳层电子结构赋予它们在电学、磁学和光学领域的特殊性质。这些性质包括延长的荧光寿命、大的斯托克斯位移、独特的光谱带以及对光漂白的强抗性，使其成为合成分子探针的理想选择。每种成像技术都有其独特的优势和特定的适用性，但由于其工作原理也存在固有的局限性。双模态分子探针有效地解决了这些局限性，特别是在涉及高分辨率磁共振成像（MRI）的应用中，如MRI/OI、MRI/PET、MRI/CT和MRI/US。本综述总结了稀土元素在这四种双成像模式中的应用、优势、挑战和当前研究现状，为稀土元素在双模态分子探针领域的未来发展和应用提供理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/a1a57d23db42/d4ra04987j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/88167c28884b/d4ra04987j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/a7fe1142de27/d4ra04987j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/8c5a61517702/d4ra04987j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/380fcb35ee72/d4ra04987j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/a1a57d23db42/d4ra04987j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/88167c28884b/d4ra04987j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/a7fe1142de27/d4ra04987j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/8c5a61517702/d4ra04987j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/380fcb35ee72/d4ra04987j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2a6/11618533/a1a57d23db42/d4ra04987j-f5.jpg

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Engineered aptamers for molecular imaging.用于分子成像的工程适配体。
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Core-multi-shell design: unlocking multimodal capabilities in lanthanide-based nanoparticles as upconverting, -weighted MRI and CT probes.
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Nanoscale. 2023 Dec 14;15(48):19546-19556. doi: 10.1039/d3nr05380f.
4
Preparation and application of carbon quantum dot fluorescent probes combined with rare earth ions.结合稀土离子的碳量子点荧光探针的制备与应用
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