Meehan R T
Ann Emerg Med. 1987 Sep;16(9):974-9. doi: 10.1016/s0196-0644(87)80743-6.
This paper is a review and interpretation of prior studies that have investigated the effects of hypoxia on immune function. A summary of current methods used to assess immune effector cell function in human beings is presented using in vitro models of mononuclear cell activation. Animal studies indicate that impaired host defenses against bacterial pathogens may be compromised, but that resistance to virus infections may remain intact. Data from human studies and animal models indicate that active immunization and B cell function are unimpaired, whereas T cell function is blunted following exposure to hypoxia. Mechanisms that may be responsible for alterations in normal immunoregulation are presented. The implications of altered immune function in subjects exposed to high altitude are discussed.
本文是对先前研究的综述与解读，这些研究调查了缺氧对免疫功能的影响。利用单核细胞激活的体外模型，介绍了目前用于评估人类免疫效应细胞功能的方法。动物研究表明，宿主对细菌病原体的防御能力受损可能会受到影响，但对病毒感染的抵抗力可能保持完好。来自人体研究和动物模型的数据表明，主动免疫和B细胞功能未受损害，而暴露于缺氧环境后T细胞功能会减弱。文中还介绍了可能导致正常免疫调节改变的机制。讨论了暴露于高海拔地区的受试者免疫功能改变的影响。
