Choremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias 8, 11527 Goudi, Athens, Greece.
Department of Life Sciences, School of Sciences, European University Cyprus, 1516 Nicosia, Cyprus.
Int J Mol Sci. 2020 Oct 15;21(20):7633. doi: 10.3390/ijms21207633.
The growth arrest-specific transcript 5 () is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.
生长停滞特异性转录物 5() 是一种 >200-nt 的 lncRNA 分子，可调节包括增殖、凋亡、侵袭和转移在内的多种细胞功能，在不同类型的人类癌症中均有体现。在此，我们综述了关于 在白血病、宫颈癌、乳腺癌、卵巢癌、前列腺癌、膀胱癌、肺癌、胃癌、结直肠癌、肝癌、骨肉瘤和脑癌中的表达的文献，以及其与各种 miRNA 的相互作用及其对这些恶性肿瘤中治疗相关耐药性的影响。普遍共识是， 在不同的肿瘤类型中均充当肿瘤抑制因子，其上调导致肿瘤对化疗或放疗敏感。 在肿瘤治疗诱导的耐药性中似乎发挥了以前未被重视但却非常重要的作用。
