Cobzeanu Bogdan Mihail, Cobzeanu Mihail Dan, Moscalu Mihaela, Palade Octavian Dragos, Rădulescu Luminița, Negru Dragoș, Moisii Liliana Gheorghe, Cobzeanu Luiza Maria, Ungureanu Loredana Beatrice, Vonica Patricia, Matei Daniela Viorelia, Rusu Daniela Carmen, Volovaț Constantin, Costan Victor Vlad
Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Medicina (Kaunas). 2020 Oct 15;56(10):542. doi: 10.3390/medicina56100542.
Knowledge of the interactions and influences of infectious, genetic, and environmental factors on the evolution and treatment response of malignant tumors is essential for improving the management of the disease and increasing patient survival. The objective of this study was to establish the contribution of human papillomavirus (HPV), as well as p53 and p16 tumor markers, alongside associated factors (smoking and alcohol consumption), in the progression of malignancies located in the oropharynx and at the retromolar trigone-oropharyngeal junction. We performed a prospective study including 50 patients with malignant tumors of the oropharynx and retromolar trigone-oropharyngeal junction. In all patients, the presence and type of HPV were determined, as well as the status of the tumor markers p53 and p16. The associated risk factors, biopsy results, treatment method, and post-treatment evolution were all documented. Statistical analyses were performed to evaluate the correlations between the determining factors and their influence on the post-treatment evolution. An overall increased survival rate was found in HPV(+) patients. Our study outlined the prevalence of different high-risk subtypes of HPV from the ones presented by other studies, suggesting a possible geographic variation. Correlations between the p53 and p16 statuses and patient survival could be established. The association of smoking and alcohol consumption strongly correlated with an unfavorable evolution. Awareness of the differences in the post-treatment evolution of the patients in relation to the presence of the factors determined in our study could change the future management of such cases for ensuring improved treatment outcomes.
了解感染、遗传和环境因素对恶性肿瘤的演变及治疗反应的相互作用和影响，对于改善疾病管理和提高患者生存率至关重要。本研究的目的是确定人乳头瘤病毒（HPV）以及p53和p16肿瘤标志物，连同相关因素（吸烟和饮酒）在口咽及磨牙后三角 - 口咽交界处恶性肿瘤进展中的作用。我们进行了一项前瞻性研究，纳入了50例口咽及磨牙后三角 - 口咽交界处恶性肿瘤患者。对所有患者确定了HPV的存在及其类型，以及肿瘤标志物p53和p16的状态。记录了相关危险因素、活检结果、治疗方法及治疗后的病情演变。进行了统计分析以评估决定性因素之间的相关性及其对治疗后病情演变的影响。发现HPV（+）患者的总体生存率有所提高。我们的研究概述了与其他研究中所呈现的不同高危HPV亚型的流行情况，提示可能存在地理差异。可以确定p53和p16状态与患者生存率之间的相关性。吸烟和饮酒的关联与不良病情演变密切相关。了解患者治疗后病情演变与我们研究中所确定因素存在与否的差异，可能会改变此类病例未来的管理方式，以确保改善治疗效果。
