Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University & Capital Medical University, Beijing, China.
Ear Nose Throat J. 2022 Aug;101(7):NP284-NP290. doi: 10.1177/0145561320963627. Epub 2020 Oct 20.
The pathologic features and potential predictive biomarkers for recurrence of antrochoanal polyps (ACPs) in children are not fully understood.
To identify the pathologic differences between recurrent and nonrecurrent group and to explore potential clinical markers which predict recurrence of ACPs in children.
A total of 11 recurrent and 21 nonrecurrent ACPs children were enrolled into this retrospect study. Clinical basic information was collected before the first surgery. The counts of vessels were evaluated by hematoxylin-eosin (HE) staining, and CD34 was detected by immunohistochemistry. Meanwhile, the percentage of each tissue inflammatory cells (eosinophils, neutrophils, lymphocytes, and plasma cells) was assessed by HE staining.
No statistical significance was observed between the 2 groups in the basic clinical features. Moreover, both the counts of blood vessels and the tissue neutrophils percentage were enhanced significantly in group with ACPs recurrence ( < .05). According to the receiver operating characteristic curves, the area under the curve for the counts of blood vessels and tissue neutrophils percentage in the prediction of ACPs' recurrence was 0.779 ( = .0105) and 0.989 ( < .0001) respectively.
It was concluded that the counts of blood vessels and the percentage of tissue neutrophils appeared to be potential excellent predictors of ACPs recurrence in children.
儿童鼻窦后鼻孔息肉（ACPs）复发的病理特征和潜在预测生物标志物尚未完全明确。
明确复发组和非复发组之间的病理差异，并探讨预测儿童 ACPs 复发的潜在临床标志物。
本回顾性研究共纳入 11 例复发和 21 例非复发 ACPs 患儿。所有患儿均在首次手术前采集临床基本信息。通过苏木精-伊红（HE）染色评估血管计数，通过免疫组织化学检测 CD34。同时，通过 HE 染色评估各组织炎症细胞（嗜酸性粒细胞、中性粒细胞、淋巴细胞和浆细胞）的百分比。
两组患儿的基本临床特征无统计学差异。此外，复发组 ACPs 患儿的血管计数和组织中性粒细胞百分比均显著增加（ <.05）。根据受试者工作特征曲线，血管计数和组织中性粒细胞百分比预测 ACPs 复发的曲线下面积分别为 0.779（ =.0105）和 0.989（ <.0001）。
血管计数和组织中性粒细胞百分比似乎是儿童 ACPs 复发的潜在优秀预测指标。
