Binder P S, Deg J K, Kohl F S
Arch Ophthalmol. 1987 Sep;105(9):1243-7. doi: 10.1001/archopht.1987.01060090101037.
A patient developed an acute onset of pseudophakic bullous keratopathy and a diffuse, gray, subepithelial corneal deposit ten days following surgery during which sodium chondroitin sulfate was used. The deposit, identified histologically as calcium, was noted throughout Bowman's layer. The absence of chronic pathologic features in the posterior cornea eliminated Fuchs' endothelial dystrophy as the cause of the acute corneal decompensation. This histopathologic confirmation of calcium deposition with one formulation of chondroitin sulfate, combined with similar conclusions from previous case reports, stimulated the reformulation of the product, which has been shown to be useful in clinical practice.
一名患者在使用硫酸软骨素的手术后十天出现了人工晶状体大泡性角膜病变急性发作，以及弥漫性、灰白色、上皮下角膜沉积物。组织学上确定该沉积物为钙，在整个Bowman层均有发现。后角膜无慢性病理特征排除了Fuchs内皮营养不良作为急性角膜失代偿的原因。这种硫酸软骨素一种制剂钙沉积的组织病理学证实，结合先前病例报告的类似结论，促使该产品重新配方，已证明在临床实践中有用。
