神经肌肉阻滞剂致咬肌瘫痪时下颌闭口力的变化：SION 咬肌瘫痪术。

Change in jaw occlusive power by paralysis of masseter muscle with a neuromuscular blocker: Sion's masseter muscle paralysis.

机构信息

Department of Emergency Medicine, Chonbuk National University Hospital; Research Institute of Clinical Medicine of Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju-si, Korea.

Research Institute of Clinical Medicine of Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital; Department of Emergency Medicine, Chonbuk National University, Jeonju-si, Korea.

出版信息

Indian J Pharmacol. 2020 Jul-Aug;52(4):324-330. doi: 10.4103/ijp.IJP_569_18.

DOI:10.4103/ijp.IJP_569_18

PMID:33078734

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7722911/

Abstract

STUDY OBJECTIVE

We aimed to determine whether jaw occlusive power decreases with the injection of neuromuscular blocking agents in masseter muscle - a method we named Sion's masseter muscle paralysis (SMP).

METHODS

A randomized, placebo-controlled animal study was conducted in which researchers were blinded to group allocation. We used 12 male mongrel dogs aged 10-12 months and weighing 30-35 kg. Four groups were formed: a conventional dose (CD) group (0.004 mg/kg succinylcholine in 4 ml normal saline [NS]); a high dose (HD) group (0.04 mg/kg succinylcholine in 4 ml NS); a placebo group (4 ml NS); and no intervention group. To measure the jaw occlusive power, 1 kg weight was hung sequentially on a specifically designed device on the animal's lower jaw. At -4, -2, 0', +2, +4, +6, +8, +10, +20, and +30 min, we measured the jaw occlusive power, oxygen saturation (SpO), and end-tidal carbon dioxide (ETCO).

RESULTS

After SMP, jaw occlusive power began to decline in CD and HD group. The arithmetical mean jaw occlusive power values at -4, -2, 0', +2, +4, +6, +8, and +10 min were 9.7, 9.7, 9.7, 8.7, 8.3, 7.3, 6.7, and 6.3 kgw in the CD group and 9.7, 9.3, 8.7, 8.0, 6.7, 5.0, 5.0, and 5.3 kgw in the HD group. No abnormalities in SpOor ETCOwere detected.

CONCLUSION

Jaw occlusive power was decreased after SMP with succinylcholine, without inducing respiratory complication.

摘要

研究目的

我们旨在确定在咬肌中注射神经肌肉阻滞剂是否会降低下颌闭合力——我们将这种方法命名为 Sion 咬肌瘫痪（SMP）。

方法

这是一项随机、安慰剂对照的动物研究，研究人员对分组情况设盲。我们使用了 12 只 10-12 个月大、体重 30-35 公斤的雄性杂种狗。将它们分为四组：常规剂量（CD）组（4 毫升生理盐水[NS]中的 0.004 毫克/千克琥珀酰胆碱）；高剂量（HD）组（4 毫升 NS 中的 0.04 毫克/千克琥珀酰胆碱）；安慰剂组（4 毫升 NS）；无干预组。为了测量下颌闭合力，将 1 公斤的重量依次挂在下颌的特制设备上。在-4、-2、0'、+2、+4、+6、+8、+10、+20 和+30 分钟时，我们测量了下颌闭合力、血氧饱和度（SpO）和呼气末二氧化碳（ETCO）。

结果

SMP 后，CD 和 HD 组的下颌闭合力开始下降。CD 组-4、-2、0'、+2、+4、+6、+8 和+10 分钟的下颌闭合力算术平均值分别为 9.7、9.7、9.7、8.7、8.3、7.3、6.7 和 6.3 公斤，HD 组分别为 9.7、9.3、8.7、8.0、6.7、5.0、5.0 和 5.3 公斤。未检测到 SpO 或 ETCO 的异常。