Emerg Infect Dis. 2020 Nov;26(11):2651-2659. doi: 10.3201/eid2611.181414.
We performed a systematic review and meta-analysis of the incidence, case-fatality rate (CFR), isolate antimicrobial resistance patterns, and serotype and sequence type distributions for invasive group B Streptococcus (GBS) disease in infants <1-89 days of age in China. We searched the PubMed/Medline, Embase, Wanfang, and China National Knowledge Infrastructure databases for research published during January 1, 2000-March 16, 2018, and identified 64 studies. Quality of included studies was assessed by using Cochrane tools. Incidence and CFR were estimated by using random-effects meta-analyses. Overall incidence was 0.55 (95% CI 0.35-0.74) cases/1,000 live births, and the CFR was 5% (95% CI 3%-6%). Incidence of GBS in young infants in China was higher than the estimated global incidence (0.49 cases/1,000 live births) and higher than previous estimates for Asia (0.3 cases/1,000 live births). Our findings suggest that implementation of additional GBS prevention efforts in China, including maternal vaccination, could be beneficial.
我们对中国 1-89 天龄婴儿侵袭性 B 组链球菌（GBS）疾病的发病率、病死率（CFR）、分离株抗菌药物耐药模式以及血清型和序列型分布进行了系统评价和荟萃分析。我们检索了 2000 年 1 月 1 日至 2018 年 3 月 16 日期间发表的在 PubMed/Medline、Embase、万方和中国国家知识基础设施数据库中的研究，共确定了 64 项研究。使用 Cochrane 工具评估纳入研究的质量。使用随机效应荟萃分析估计发病率和 CFR。总体发病率为 0.55（95%CI 0.35-0.74）例/1000 活产儿，CFR 为 5%（95%CI 3%-6%）。中国的婴儿发病率高于全球估计发病率（0.49 例/1000 活产儿），也高于亚洲之前的估计（0.3 例/1000 活产儿）。我们的研究结果表明，在中国实施更多的 GBS 预防措施，包括对母亲进行疫苗接种，可能是有益的。
