Department of Nephrology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China.
Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China.
Abdom Radiol (NY). 2021 May;46(5):2032-2044. doi: 10.1007/s00261-020-02794-y. Epub 2020 Oct 20.
Renal microstructure and function are closely associated with oxygenation homeostasis. Analyzing renal blood oxygen level‒dependent (BOLD) magnetic resonance imaging (MRI) examination results will provide information on the biological status of the kidneys. The current study was performed to explore the hypoxia mode of the entire renal parenchyma in patients with lupus nephritis (LN).
A total of 23 adult patients with LN and 18 healthy volunteers were recruited. R* values were acquired using BOLD MRI analysis. The narrow rectangular region of interest was used to explore the hypoxia configuration in entire depths of renal parenchyma. Acquired sequential R* data were fitted using four categories of mathematic functions. The tendency of R* data in both patients with LN and healthy volunteers was also compared using repeated-measures analysis of variance.
R* data from the superficial cortex to deep medulla displayed two patterns called a sharp uptrend style and a flat uptrend style. After sequential R* data were fitted individually with the use of four mathematic formulas, the multiple-compartment Gaussian function showed the highest goodness of fit. Compared with two categories of R* value styles, the R* tendency of entire parenchyma in patients with LN was different from that in healthy volunteers.
Deep renal medullary oxygenation was not always overtly lower than oxygenation in the superficial renal cortical zone. The manifestation of renal parenchyma oxygenation could be described using a Gaussian function model. Deoxygenation tolerance was damaged in patients with LN.
肾脏的微观结构和功能与氧合状态密切相关。分析肾脏血氧水平依赖（BOLD）磁共振成像（MRI）检查结果将提供有关肾脏生物学状态的信息。本研究旨在探讨狼疮性肾炎（LN）患者整个肾实质的缺氧模式。
共纳入 23 例成人 LN 患者和 18 名健康志愿者。使用 BOLD MRI 分析获得 R* 值。使用窄矩形感兴趣区来探索整个肾实质深度的缺氧结构。使用四类数学函数拟合获得的顺序 R数据。使用重复测量方差分析比较 LN 患者和健康志愿者的 R数据趋势。
从肾皮质表面到肾髓质深部的 R数据呈现两种模式，分别称为急剧上升趋势和平坦上升趋势。对顺序 R数据分别使用四个数学公式进行拟合后，多腔高斯函数的拟合效果最佳。与两种 R值模式相比，LN 患者整个肾实质的 R趋势与健康志愿者不同。
肾髓质深部的氧合并不总是明显低于肾皮质表面的氧合。肾实质氧合的表现可以用高斯函数模型来描述。LN 患者的耐缺氧能力受损。
