Ong Lawrence T C, Booth David R, Parnell Grant P
Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, The University of Sydney, 176 Hawkesbury Rd, Westmead, New South Wales, 2145, Australia.
Department of Immunology, Westmead Hospital, Cnr Darcy and Hawkesbury Rds, Westmead, New South Wales, 2145, Australia.
Mol Nutr Food Res. 2020 Dec;64(23):e2000437. doi: 10.1002/mnfr.202000437. Epub 2020 Oct 29.
DNA methylation is increasingly being recognized as a mechanism through which environmental exposures confer disease risk. Several studies have examined the association between vitamin D and changes in DNA methylation in areas as diverse as human and animal development, genomic stability, chronic disease risk, and malignancy. In many cases, they have demonstrated clear associations between vitamin D and DNA methylation in candidate disease pathways. Despite this, a clear understanding of the mechanisms by which these factors interact is unclear. This paper reviews the current understanding of the effects of vitamin D on DNA methylation. In light of current knowledge in the field, the potential mechanisms mediating vitamin D effects on DNA methylation are discussed, as are the limiting factors and future avenues for research into this exciting area.
DNA甲基化日益被视为一种环境暴露赋予疾病风险的机制。多项研究已考察了维生素D与DNA甲基化变化之间的关联，这些变化涉及人类和动物发育、基因组稳定性、慢性病风险及恶性肿瘤等诸多领域。在许多情况下，它们已证明在候选疾病途径中维生素D与DNA甲基化之间存在明确关联。尽管如此，对于这些因素相互作用的机制仍缺乏清晰认识。本文综述了当前对维生素D对DNA甲基化影响的理解。鉴于该领域的现有知识，讨论了介导维生素D对DNA甲基化影响的潜在机制，以及该令人兴奋领域的限制因素和未来研究方向。
