Wardhani I K, Mathôt S, Boehler C N, Laeng B
Department of Psychology, University of Oslo, Forskningsveien 3A, 0373 Oslo, Norway; Department of Experimental Psychology, University of Groningen, Grote Kruisstraat 2/1, 9712 TS Groningen, the Netherlands; Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, 9000 Ghent, Belgium.
Department of Experimental Psychology, University of Groningen, Grote Kruisstraat 2/1, 9712 TS Groningen, the Netherlands.
Int J Psychophysiol. 2020 Dec;158:45-55. doi: 10.1016/j.ijpsycho.2020.09.005. Epub 2020 Oct 17.
Nicotine has been commonly used in pyschopharmacological studies, showing its benefits as a pharmacological stimulant on cognitive performance. In the current study, we investigated the effects of 2 mg (Experiment 1) and 4 mg (Experiment 2) of nicotine on performance on a multiple-object-tracking task. Participants were young non-smoking adults with no pre-existing attentional deficits. Nicotine and placebo were administered through nicotine and nicotine-free taste-matched chewing gum, respectively. Additionally, we compared pupil size between nicotine and placebo conditions in both experiments. Although we found that pupil size was considerably smaller in the nicotine conditions, nicotine administration did not appear to facilitate behavioural performance. We speculate that nicotine might enhance performance only for certain cognitive functions, and only for specific populations, such as nicotine-deprived smokers.
尼古丁已普遍用于精神药理学研究，显示出其作为一种药理兴奋剂对认知表现的益处。在当前的研究中，我们调查了2毫克（实验1）和4毫克（实验2）尼古丁对多目标追踪任务表现的影响。参与者是没有预先存在注意力缺陷的年轻非吸烟成年人。尼古丁和安慰剂分别通过含尼古丁和不含尼古丁的口味匹配口香糖给药。此外，我们在两个实验中比较了尼古丁和安慰剂条件下的瞳孔大小。尽管我们发现尼古丁条件下的瞳孔大小明显较小，但尼古丁给药似乎并未促进行为表现。我们推测，尼古丁可能仅对某些认知功能有增强作用，且仅对特定人群，如尼古丁缺乏的吸烟者有此作用。
