Fetal Medicine Department, Sorbonne University, AP-HP, Armand Trousseau Hospital, National Rare Disease Centre for Spinal and Vertebral Anomalies (MAVEM CENTER), 75012 Paris, France.
INSERM U1142 (LIMICS), Sorbonne University, 75005 Paris, France.
Nutrients. 2020 Oct 16;12(10):3170. doi: 10.3390/nu12103170.
Folic acid supplementation is recommended for neural tube defect prevention during pregnancy. We conducted an observational, retrospective national registry study to determine the rate of dispensing of periconceptional folic acid after prescription in a sample of French women representative of the general population. Our study population ( = 186,061) was a representative sample of the French population, recorded in the Health Data System database on pharmacy dispensing of medication and mandatory reporting of pregnancy. Between 2006 and 2016, 14.3% of pregnant women had a prescription for folic acid supplementation during the month preceding conception and for the first 12 weeks of pregnancy. Of these prescriptions, 30.9% were issued before the start of pregnancy. This percentage was lower for first pregnancies. The rate of pharmacy dispensing during the preconception period increased progressively from 3.8% to 8.3% between 2006 and 2016. In France, the rate of pharmacy dispensing of periconceptional folic acid after medical prescription is very low and does not follow international recommendations. It seems essential to implement awareness-raising policies targeting the general population and physicians regarding effective periconceptional supplementation, particularly starting in the preconception period. Clarification of international recommendations and fortification of flour could improve the efficacy of folate supplementation at population level.
建议在怀孕期间补充叶酸以预防神经管缺陷。我们进行了一项观察性、回顾性的全国登记研究，以确定在具有代表性的法国一般人群样本中，在开具处方后，围孕期叶酸的配药率。我们的研究人群（n=186061）是法国人口的代表性样本，记录在药房配药药物和妊娠强制报告的健康数据系统数据库中。在 2006 年至 2016 年期间，14.3%的孕妇在受孕前一个月和妊娠的前 12 周有补充叶酸的处方。这些处方中，30.9%是在怀孕前开具的。对于首次怀孕的孕妇，这一比例较低。在备孕期间的配药率从 2006 年的 3.8%逐渐增加到 2016 年的 8.3%。在法国，医疗处方后围孕期叶酸的配药率非常低，不符合国际建议。似乎有必要针对一般人群和医生实施提高认识的政策，以提高围孕期补充叶酸的有效性，特别是从备孕开始。明确国际建议并强化面粉中的叶酸可以提高叶酸补充剂在人群中的效果。
