紧紧拥抱并保持紧密：二聚化控制泛素结合酶 UBE2S 的周转率。
Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S.
机构信息
Institute of Biochemistry II, Goethe University Frankfurt-Medical Faculty, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Email:
出版信息
Sci Signal. 2020 Oct 20;13(654):eabd9892. doi: 10.1126/scisignal.abd9892.
PMID:33082290
Abstract
Precise control of the activity and abundance of ubiquitin-conjugating enzymes (E2s) ensures fidelity in ubiquitin chain synthesis. In this issue of , Liess demonstrate that the human anaphase-promoting complex (APC/C)-associated E2 UBE2S adopts an autoinhibited dimeric state that increases the half-life of UBE2S by preventing its autoubiquitination-driven turnover.
摘要
精确控制泛素连接酶（E2s）的活性和丰度可确保泛素链合成的保真度。在本期 杂志中，Liess 等人证明，与有丝分裂后期促进复合物（APC/C）相关的 E2 UBE2S 采用自动抑制的二聚体状态，通过阻止其自身泛素化驱动的周转来增加 UBE2S 的半衰期。
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