Ge Yongpeng, He Linrong
Department of Rheumatology, China-Japan Friendship Hospital Yinghua East Road, Chaoyang District 100029, Beijing, China.
Case Rep Rheumatol. 2020 Oct 7;2020:8840642. doi: 10.1155/2020/8840642. eCollection 2020.
Both axial spondyloarthritis (axSpA) and idiopathic inflammatory myopathy (IIM) are infrequent, and their coexistence is even rarer; there are a few reported cases in the literature. The aim of this study was to assess their association and clinical and laboratory features in our patients. The clinical data of patients with axSpA and IIM diagnosed in China-Japan Friendship Hospital from July 2015 to February 2019 were retrospectively analyzed. This study included 7 patients with axSpA who met the IIM criteria, including 3 males and 4 females. The age of onset was 16 to 39 years. Four patients were HLA-B27 positive, and three were negative. All patients were first diagnosed as axSpA, and then IIM was detected after 0.5-20 years (mean ± SD, 9.9 ± 5.0 years). After being diagnosed to have axSpA and IIM, those patients were given prednisone and immunosuppressant drugs, and their symptoms gradually improved. Our study provides further evidence of the coexistence of IIM with axSpA. In patients with axSpA who have skin rash, interstitial lung disease (ILD), myalgia, or muscle weakness, we should suspect that they may have IIM.
轴性脊柱关节炎（axSpA）和特发性炎性肌病（IIM）均较为少见，二者并存的情况更为罕见；文献中仅有少数病例报道。本研究旨在评估我院患者中二者的关联以及临床和实验室特征。回顾性分析了2015年7月至2019年2月在中国-日本友好医院诊断为axSpA和IIM的患者的临床资料。本研究纳入了7例符合IIM标准的axSpA患者，其中男性3例，女性4例。发病年龄为16至39岁。4例患者HLA-B27阳性，3例阴性。所有患者最初均被诊断为axSpA，0.5至20年后（平均±标准差，9.9±5.0年）检测出IIM。诊断为axSpA和IIM后，给予这些患者泼尼松和免疫抑制药物治疗，症状逐渐改善。我们的研究为IIM与axSpA并存提供了进一步证据。对于有皮疹、间质性肺病（ILD）、肌痛或肌无力的axSpA患者，我们应怀疑其可能患有IIM。
