Stepanović Aleksandar, Nikitović Marina, Bogdanović Andrija, Grujičić Danica
Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Eur J Case Rep Intern Med. 2020 Jul 7;7(10):001785. doi: 10.12890/2020_001785. eCollection 2020.
We describe long-lasting and incompletely resolved thrombocytopenia after transient profound pancytopenia in a 62-year-old female patient with glioblastoma after short-term radiotherapy with temozolomide. Pancytopenia was present for more than 4 weeks and thrombocytopenia for more than 6 months, without platelet recovery to normal levels.
Some patients may experience severe haematological manifestations after even short-term radiotherapy with temozolomide.In everyday practice, clinical models precisely predicting the haematological toxicity of concomitant treatment with temozolomide and radiotherapy is necessary, especially in countries where genetic tests are not available.Incomplete recovery of the cells of a particular bloodline over a long period may necessitate permanent discontinuation of chemotherapy or radiotherapy.
我们描述了一名62岁胶质母细胞瘤女性患者在接受替莫唑胺短期放疗后出现短暂性全血细胞减少后持续存在且未完全缓解的血小板减少症。全血细胞减少持续超过4周，血小板减少持续超过6个月，血小板未恢复至正常水平。
即使是接受替莫唑胺短期放疗，一些患者也可能出现严重的血液学表现。在日常实践中，精确预测替莫唑胺与放疗联合治疗血液学毒性的临床模型是必要的，尤其是在无法进行基因检测的国家。特定血统细胞长期未完全恢复可能需要永久停止化疗或放疗。
