Olsson Mägi Caroline-Aleksi, Bjerg Bäcklund Anders, Lødrup Carlsen Karin, Almqvist Catarina, Carlsen Kai-Håkon, Granum Berit, Haugen Guttorm, Hilde Katarina, Lødrup Carlsen Oda C, Jonassen Christine Monceyron, Rehbinder Eva Maria, Sjøborg Katrine D, Skjerven Håvard, Staff Anne Cathrine, Vettukattil Riyas, Söderhäll Cilla, Nordlund Björn
Dept of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
ERJ Open Res. 2020 Oct 13;6(4). doi: 10.1183/23120541.00175-2020. eCollection 2020 Oct.
Maternal stress during pregnancy may negatively affect the health of mother and child. We therefore aimed to identify the proportion of women reporting high maternal stress in mid and late pregnancy and explore whether symptoms of maternal allergic disease are associated with perceived maternal stress in late pregnancy.
The population-based Preventing Atopic Dermatitis and Allergy in Children (PreventADALL) study enrolled 2697 pregnant women at their 18-week routine ultrasound examination in Norway and Sweden. Information about sociodemographic factors, symptoms and doctor-diagnosed asthma, allergic rhinitis, atopic dermatitis, food allergy, and anaphylaxis and stress using the 14-item perceived stress scale (PSS) was collected at 18 weeks (mid) and 34 weeks (late) pregnancy. High stress was defined as a PSS score ≥29. Scores were analysed using multivariate logistic and linear regression.
Among the 2164 women with complete PSS data, 17% reported asthma, 20% atopic dermatitis, 23% allergic rhinitis, 12% food allergy and 2% anaphylaxis. The proportion of women reporting high stress decreased from 15% at mid to 13% at late pregnancy (p<0.01). The adjusted odds ratio for high stress in late pregnancy was 2.25 (95% CI 1.41-3.58) for self-reported symptoms of asthma, 1.46 (95% CI 1.02-2.10) for allergic rhinitis and 2.25 (95% CI 1.32-3.82) for food allergy. A multivariate linear regression model confirmed that symptoms of asthma (β coefficient 2.11; 0.71-3.51), atopic dermatitis (β coefficient 1.76; 0.62-2.89) and food allergy (β coefficient 2.24; 0.63-3.84) were independently associated with increased PSS score.
Allergic disease symptoms in pregnancy were associated with increased stress, highlighting the importance of optimal disease control in pregnancy.
孕期母亲压力可能会对母婴健康产生负面影响。因此，我们旨在确定妊娠中晚期报告有高母亲压力的女性比例，并探讨母亲过敏性疾病症状是否与妊娠晚期感知到的母亲压力相关。
基于人群的“预防儿童特应性皮炎和过敏”（PreventADALL）研究在挪威和瑞典对2697名孕妇进行了18周常规超声检查时入组。在妊娠18周（中期）和34周（晚期）收集了有关社会人口学因素、症状以及医生诊断的哮喘、过敏性鼻炎、特应性皮炎、食物过敏、过敏反应和使用14项感知压力量表（PSS）评估的压力的信息。高压力定义为PSS评分≥29。使用多变量逻辑回归和线性回归分析得分。
在2164名有完整PSS数据的女性中，17%报告有哮喘，20%有特应性皮炎，23%有过敏性鼻炎，12%有食物过敏，2%有过敏反应。报告有高压力的女性比例从妊娠中期的15%降至晚期的13%（p<0.01）。妊娠晚期高压力的校正比值比，自我报告的哮喘症状为2.25（95%CI 1.41 - 3.58），过敏性鼻炎为1.46（95%CI 1.02 - 2.10），食物过敏为2.25（95%CI 1.32 - 3.82）。多变量线性回归模型证实，哮喘症状（β系数2.11；0.71 - 3.51）、特应性皮炎（β系数1.76；0.62 - 2.89）和食物过敏（β系数2.24；0.63 - 3.84）与PSS评分增加独立相关。
孕期过敏性疾病症状与压力增加相关，突出了孕期最佳疾病控制的重要性。
