Iftikhar Waleed, Cheema Fatima Fayyaz, Khanal Sneha, Khan Qudsia Umaira
CMH Lahore Medical College and Institute of Dentistry (NUMS), Lahore, Pakistan.
Jahurul Islam Medical College and Hospital, Bajitpur, Kishoregonj, Bangladesh.
Discoveries (Craiova). 2020 Aug 12;8(3):e112. doi: 10.15190/d.2020.9.
Migraine is a very common disorder of the nervous system. It shares similar physiological processes with stroke. Migrainous infarction is a rare complication of migraine with aura. The neuro-logical symptoms of migraine aura correspond to the cortical spreading depression and this depression can lead to a migrainous infarction. It is pertinent to state that the investigation and detection of the cortical depression might have a great clinical significance. Blood vessels in the cranium play an important role in the pathophysiology of migraine. In the case of injured states of brain, the cortical spreading depression causes extreme vasoconstriction rather than vasodilation. The endothelial damage caused by the cortical spreading depression can result in hypercoagulability, leading to an increased risk of stroke. There are many genetic disorders in which migraine and stroke are the major symptoms and an insight into these disorders can help us in the understanding of complex mechanisms of migrainous infarction. It is pertinent to state that some derangements in the vascular function accompany migraine which may also serve as targets for research and treatment. This article will describe the hemodynamic and genetic relationship between migraine induced stroke and how it relates to the cortical spreading depression.
偏头痛是一种非常常见的神经系统疾病。它与中风有着相似的生理过程。偏头痛性脑梗死是伴有先兆偏头痛的一种罕见并发症。偏头痛先兆的神经症状与皮层扩散性抑制相对应，这种抑制可导致偏头痛性脑梗死。需要指出的是，对皮层抑制的研究和检测可能具有重大的临床意义。颅骨中的血管在偏头痛的病理生理学中起着重要作用。在脑损伤状态下，皮层扩散性抑制会导致极度血管收缩而非血管扩张。皮层扩散性抑制引起的内皮损伤可导致血液高凝状态，从而增加中风风险。有许多遗传疾病以偏头痛和中风为主要症状，深入了解这些疾病有助于我们理解偏头痛性脑梗死的复杂机制。需要指出的是，偏头痛伴有一些血管功能紊乱，这也可能成为研究和治疗的靶点。本文将描述偏头痛诱发中风之间的血流动力学和遗传关系，以及它与皮层扩散性抑制的关系。
