Piano Carla, Ciavarro Marco, Bove Francesco, Di Giuda Daniela, Cocciolillo Fabrizio, Bentivoglio Anna Rita, Cioni Beatrice, Tufo Tommaso, Calabresi Paolo, Daniele Antonio
Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
IRCCS Neuromed, Pozzilli, Italy.
NPJ Parkinsons Dis. 2020 Sep 28;6:26. doi: 10.1038/s41531-020-00129-8. eCollection 2020.
Electric Extradural Motor Cortex Stimulation (EMCS) is a neurosurgical procedure suggested for treatment of patients with advanced Parkinson's disease (PD). We report two PD patients treated by EMCS, who experienced worsening of motor symptoms and cognition 5 years after surgery, when EMCS batteries became discharged. One month after EMCS restoration, they experienced a subjective improvement of motor symptoms and cognition. Neuropsychological assessments were carried out before replacement of batteries (off-EMCS condition) and 6 months afterward (on-EMCS condition). As compared to off-EMCS condition, in on-EMCS condition both patients showed an improvement on tasks of verbal episodic memory and backward spatial short-term/working memory task, and a decline on tasks of selective visual attention and forward spatial short-term memory. These findings suggest that in PD patients EMCS may induce slight beneficial effects on motor symptoms and cognitive processes involved in verbal episodic memory and in active manipulation of information stored in working memory.
硬膜外电刺激运动皮层（EMCS）是一种用于治疗晚期帕金森病（PD）患者的神经外科手术。我们报告了两名接受EMCS治疗的PD患者，他们在手术后5年，当EMCS电池电量耗尽时，运动症状和认知功能恶化。在EMCS恢复一个月后，他们的运动症状和认知功能主观上有所改善。在更换电池前（EMCS关闭状态）和之后6个月（EMCS开启状态）进行了神经心理学评估。与EMCS关闭状态相比，在EMCS开启状态下，两名患者在言语情景记忆任务和逆向空间短期/工作记忆任务上均有改善，而在选择性视觉注意力任务和正向空间短期记忆任务上则有所下降。这些发现表明，在PD患者中，EMCS可能对运动症状以及言语情景记忆和工作记忆中信息的主动处理所涉及的认知过程产生轻微的有益影响。
