Porta M S, Hartzema A G
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27514.
Drug Intell Clin Pharm. 1987 Sep;21(9):741-7. doi: 10.1177/106002808702100916.
Epidemiology is concerned with the distribution of disease and health in human populations. Drugs are one of the factors that influence such a distribution. Pharmacoepidemiology can be defined as the application of epidemiologic knowledge, methods, and reasoning to the study of the effects (beneficial and adverse) and uses of drugs in human populations. Pharmacoepidemiology aims to describe, explain, control, and predict the effects and uses of pharmacologic treatment modalities in a defined time, space, and population. The present article is an introduction to the contributions of epidemiology to the study of drugs.
流行病学关注疾病和健康在人群中的分布情况。药物是影响这种分布的因素之一。药物流行病学可定义为将流行病学知识、方法和推理应用于研究药物在人群中的效应(有益和有害)及使用情况。药物流行病学旨在描述、解释、控制并预测在特定的时间、空间和人群中药物治疗方式的效应及使用情况。本文是对流行病学在药物研究方面所做贡献的介绍。