Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100871, China.
Institute of Nephrology, Peking University, Beijing 100871, China.
J Proteome Res. 2020 Nov 6;19(11):4374-4379. doi: 10.1021/acs.jproteome.0c00671. Epub 2020 Oct 21.
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted a large portion of the world population. From a virus genetic perspective, a recent study described what genomic data revealed about the origin and emergence of SARS-CoV-2, proposing stronger action against illegal wildlife trade. In the current "big data" era, an increasing number of large-scale, multidimensional omics data sets were publicly available. Herein, we review how human genetics tells us about the transmission, pathogenesis, susceptibility, severity, and drug prioritization of COVID-19. We further drafted a genetic roadmap of COVID-19, which was also expected to be applicable to other viruses with known receptors. Our review provides insights into the way of understanding a pandemic from a human genetic perspective.
新型冠状病毒病 2019（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的，已对世界上很大一部分人口造成影响。从病毒遗传学的角度来看，最近的一项研究描述了基因组数据揭示的 SARS-CoV-2 的起源和出现情况，提出了加强打击非法野生动物贸易的行动。在当前的“大数据”时代，越来越多的大规模、多维组学数据集可供公开使用。在此，我们回顾了人类遗传学如何告诉我们关于 COVID-19 的传播、发病机制、易感性、严重程度和药物优先级。我们进一步起草了 COVID-19 的遗传路线图，该路线图也有望适用于其他已知受体的病毒。我们的综述从人类遗传的角度提供了对大流行的理解方式。
