骨形态发生蛋白1/类 tolloid 蛋白酶家族在牙齿与骨骼发育中的作用
[Role of bone morphogenetic protein 1/tolloid proteinase family in the development of teeth and bone].
作者信息
Xie Xu-Dong, Zhao Lei, Wu Ya-Fei, Wang Jun
机构信息
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Oct 1;38(5):589-593. doi: 10.7518/hxkq.2020.05.020.
The bone morphogenetic protein (BMP) 1/tolloid (TLD) proteinase family is a group of important metalloproteinases, which play key roles in the growth and development of tissues and organs via regulating the biosynthetic processing of the extracellular matrix. Clinical reports have revealed that mutations in the genes encoding BMP1/TLD proteinases lead to dentinogenesis imperfecta type Ⅰ, accompanied with osteogenesis imperfecta. Therefore, this proteinase family is essential for the development of hard tissues. In this study, we review the research progress in the function and mechanism of the BMP1/TLD proteinase family in the development of teeth and bone.
骨形态发生蛋白（BMP）1/类 tolloid（TLD）蛋白酶家族是一组重要的金属蛋白酶，它们通过调节细胞外基质的生物合成加工过程，在组织和器官的生长发育中发挥关键作用。临床报告显示，编码 BMP1/TLD 蛋白酶的基因突变会导致Ⅰ型牙本质发育不全，并伴有成骨不全。因此，该蛋白酶家族对于硬组织的发育至关重要。在本研究中，我们综述了 BMP1/TLD 蛋白酶家族在牙齿和骨骼发育中的功能及机制的研究进展。
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