National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, Jiangxi 330022, China.
Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.
Org Lett. 2020 Nov 6;22(21):8302-8306. doi: 10.1021/acs.orglett.0c02949. Epub 2020 Oct 21.
We have developed a cyanide-free strategy for the synthesis of glycosyl carboxylic acids, which can provide 1,2- or 1,2- glycosyl carboxylic acids and is compatible with common protecting groups. The synthetic utility was demonstrated by the synthesis of 12 unreported glycosyl acids and the total synthesis of scleropentaside A.
我们开发了一种无氰化物策略，用于合成糖基羧酸，该策略可以提供 1,2-或 1,2-糖苷基羧酸，并且与常见的保护基兼容。通过合成 12 种未报道的糖苷酸和 scleropentaside A 的全合成，展示了该合成方法的实用性。
