Head and Neck Oncology Division, Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Acta Otolaryngol. 2021 Jan;141(1):106-110. doi: 10.1080/00016489.2020.1821915. Epub 2020 Oct 21.
Cases of Human papillomavirus (HPV)-associated oral and oropharyngeal cancer are increasing. Proper diagnostic tools are required to detect HPV among patients, especially in areas where high technology is lacking.
To provide mapping of HPV prevalence in Southeast Asia and to determine the effectivity of p16 as a surrogate biomarker for HPV infection in oral and oropharyngeal cancer.
Medical records of 56 patients diagnosed with oral and oropharyngeal squamous cell carcinomas (SCC) were reviewed. HPV PCR DNA and p16 immunohistochemistry (IHC) examination were performed to detect HPV positivity.
HPV PCR prevalence in oropharyngeal SCC is 42.9% and 28.6% in oral SCC. P16 IHC has 67% sensitivity and 75% specificity in detecting HPV in oropharyngeal cancer, and 33% and 72% in oral cancer.
We conclude that p16 IHC with a 5% cut-off can be used as a surrogate biomarker for oropharyngeal SCC, but not oral SCC, in areas where resources are restricted. However, further diagnostic tools may be needed.
人乳头瘤病毒（HPV）相关的口腔和口咽癌病例正在增加。需要适当的诊断工具来在患者中检测 HPV，特别是在缺乏高科技的地区。
提供东南亚 HPV 流行率的图谱，并确定 p16 作为口腔和口咽癌 HPV 感染的替代生物标志物的有效性。
回顾了 56 例诊断为口腔和口咽鳞状细胞癌（SCC）的患者的病历。进行 HPV PCR DNA 和 p16 免疫组织化学（IHC）检查以检测 HPV 阳性。
在口咽 SCC 中 HPV PCR 的流行率为 42.9%，在口腔 SCC 中为 28.6%。p16 IHC 在检测口咽癌中的 HPV 时具有 67%的敏感性和 75%的特异性，在检测口腔癌时具有 33%的敏感性和 72%的特异性。
我们的结论是，在资源有限的地区，p16 IHC 可以使用 5%的截断值作为口咽 SCC 的替代生物标志物，但不能作为口腔 SCC 的替代生物标志物。但是，可能需要进一步的诊断工具。
