Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
J Clin Pharm Ther. 2021 Feb;46(1):4-16. doi: 10.1111/jcpt.13264. Epub 2020 Oct 21.
The incidence of diabetes has been rising worldwide and is expected to increase to affect 591.9 million people by 2035 in China. Strict control of blood glucose can significantly reduce the risk of diabetic complications, but traditional interventions lack continuity, timeliness and teleonomy. The development of mobile health management has become a hot topic, as a very popular app in China, WeChat platform, has a large number of users every day. Many studies show the health management of patients with diabetes through WeChat can achieve the ideal effect. This study aims to evaluate the application of WeChat based on clinical research data, provide clinical evidence for medical staff and promote the self-management of patients with diabetes.
The PubMed, EMBASE, Cochrane Library, CNKI and Wanfang database were searched to identify related reports that were published up to 9 March 2020. The quality of included studies was assessed by Cochrane Collaboration risk assessment tool. Measures of interest were mean difference (MD) and 95% confidence interval (CI). Random-effect model was used according to the absence or presence of significant heterogeneity. Heterogeneity among trials was evaluated by I test. Publication bias was assessed by funnel plots.
Thirty-eight articles involved 2,709 controls and 2,709 patients who used WeChat were identified. Relative to the traditional group, WeChat group had a lower level in fasting plasma glucose (FPG in mmol/L; MD: 1.36, 95% CI 1.10-1.62, P < .00001), so did 2hPG (MD: 1.91, 95% CI 1.48-2.35, P < .00001) and HbA1C (MD: 1.07, 95% CI 0.86-1.27, P < .00001). Self-efficacy scale improved significantly, including diet score (MD: -1.31, 95% CI -1.77 to -0.86, P < .00001), exercise score (MD: -1.92, 95% CI -2.44 to -1.40, P < .00001), medication taking score (MD: -1.45, 95% CI: -1.94 to -0.97, P < .00001), monitoring of blood glucose score (MD: -1.17, 95% CI -1.83--0.51, P = .0005) and foot care score (MD: -1.71, 95% CI -2.08 to -1.34, P < .00001). Patients' understanding of the disease and satisfaction with follow-up increased significantly, whereas the incidence of adverse reactions and complications decreased.
WeChat follow-up appears to be helpful to improve the level of blood glucose and self-management, reduce the incidence of adverse reactions and complications, and improve the satisfaction rate of patients with type 2 diabetes. It should be noted that this meta-analysis has limitations, such as small sample sizes and the low quality of included literature, as well as the lack of research in Western countries. Therefore, more high-quality studies with larger samples are needed in the future to verify our results.
全球糖尿病发病率不断上升,预计到 2035 年中国将有 5.919 亿人受到影响。严格控制血糖可以显著降低糖尿病并发症的风险,但传统干预措施缺乏连续性、及时性和目的性。移动医疗管理的发展已成为热门话题,微信作为中国非常流行的应用程序,每天都有大量用户。许多研究表明,通过微信对糖尿病患者进行健康管理可以达到理想的效果。本研究旨在基于临床研究数据评估微信的应用,为医务人员提供临床证据,并促进糖尿病患者的自我管理。
检索 PubMed、EMBASE、Cochrane Library、CNKI 和万方数据库,以确定截至 2020 年 3 月 9 日发表的相关报告。使用 Cochrane 协作风险评估工具评估纳入研究的质量。感兴趣的措施为均数差(MD)和 95%置信区间(CI)。根据是否存在显著异质性,使用随机效应模型。通过 I 检验评估试验间的异质性。使用漏斗图评估发表偏倚。
共纳入 38 篇文章,涉及 2709 例对照组和 2709 例使用微信的患者。与传统组相比,微信组空腹血糖(mmol/L;MD:1.36,95%CI 1.10-1.62,P<.00001)、餐后 2h 血糖(MD:1.91,95%CI 1.48-2.35,P<.00001)和糖化血红蛋白(MD:1.07,95%CI 0.86-1.27,P<.00001)水平较低。自我效能量表显著改善,包括饮食评分(MD:-1.31,95%CI-1.77 至-0.86,P<.00001)、运动评分(MD:-1.92,95%CI-2.44 至-1.40,P<.00001)、服药评分(MD:-1.45,95%CI:-1.94 至-0.97,P<.00001)、血糖监测评分(MD:-1.17,95%CI-1.83-0.51,P=.0005)和足部护理评分(MD:-1.71,95%CI-2.08 至-1.34,P<.00001)。患者对疾病的了解程度和对随访的满意度显著提高,而不良反应和并发症的发生率降低。
微信随访似乎有助于改善血糖水平和自我管理,降低不良反应和并发症的发生率,并提高 2 型糖尿病患者的满意度。值得注意的是,本荟萃分析存在一定局限性,例如样本量较小,纳入文献质量较低,以及西方国家缺乏研究。因此,未来需要更多高质量、大样本的研究来验证我们的结果。