Department of Physiology, Amsterdam UMC, Vrije Universiteit, Amsterdam Cardiovascular Sciences, 1081 Hz Amsterdam, The Netherlands.
Cells. 2020 Oct 19;9(10):2317. doi: 10.3390/cells9102317.
The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing and changes in lifestyle. Prevailing theories about the mechanisms of cardiac disease onset feature the gradual derailment of cellular protein homeostasis (proteostasis) and loss of the protein quality control as central factors. In the heart, loss of protein patency, due to flaws in design (genetically) or environmentally-induced wear and tear, may overwhelm protein quality control, thereby triggering derailment of proteostasis and contributing to cardiac disease onset.
由于人口老龄化和生活方式的改变，全球范围内心脏病的发病率和患病率（主要死因）可能会增加。目前关于心脏病发病机制的主流理论主要集中在细胞蛋白质稳态（蛋白质平衡）逐渐脱轨以及蛋白质质量控制丧失这两个核心因素上。在心脏中，由于设计缺陷（遗传因素）或环境引起的磨损，蛋白质通透性丧失，可能会超过蛋白质质量控制，从而导致蛋白质平衡脱轨，并导致心脏病的发生。
