Puxeddu Efisio, Tallini Giovanni, Vanni Roberta
Department of Medicine, University of Perugia, 06123 Perugia, Italy.
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna School of Medicine, 40126 Bologna, Italy.
Cancers (Basel). 2020 Oct 19;12(10):3036. doi: 10.3390/cancers12103036.
The incidence of thyroid cancer has increased over the past 3 to 4 decades. Nonetheless, the mortality from thyroid cancer has remained stable. The thyroid gland may develop nodules encompassing several types of cell proliferation, from frankly benign to very aggressive forms with many intermediate challenging variants. For this reason, there is growing interest in evaluating thyroid nodules from many points of view, from the clinical to the molecular aspects, in the search for innovative diagnostic and prognostic parameters. The aim of this Special Issue was to provide an overview of recent developments in understanding the biology and molecular oncology of thyroid tumors of follicular cell derivation and their repercussions on the diagnosis, prognosis, and therapy. The contributions of many experts in the field made up a Special Issue of Cancers journal, that focusing on different aspects, including mechanistic and functional facets, gives the status of art of clinical and biological perspectives of thyroid cancer.
在过去的3至4十年间，甲状腺癌的发病率有所上升。尽管如此，甲状腺癌的死亡率一直保持稳定。甲状腺可能会出现包含多种细胞增殖类型的结节，从明显良性到极具侵袭性的类型，还有许多具有挑战性的中间变体。因此，从临床到分子层面，从多个角度评估甲状腺结节的兴趣与日俱增，旨在寻找创新的诊断和预后参数。本期特刊的目的是概述在理解滤泡细胞来源的甲状腺肿瘤的生物学和分子肿瘤学及其对诊断、预后和治疗的影响方面的最新进展。该领域众多专家的贡献构成了《Cancers》杂志的一期特刊，该特刊聚焦于不同方面，包括机制和功能层面，呈现了甲状腺癌临床和生物学视角的最新状况。
