人类 DNA 连接酶在复制和修复中的作用。
Human DNA ligases in replication and repair.
机构信息
Departments of Internal Medicine, Molecular Genetics and Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, United States.
Departments of Internal Medicine, Molecular Genetics and Microbiology and the University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87131, United States.
出版信息
DNA Repair (Amst). 2020 Sep;93:102908. doi: 10.1016/j.dnarep.2020.102908.
Abstract
To ensure genome integrity, the joining of breaks in the phosphodiester backbone of duplex DNA is required during DNA replication and to complete the repair of almost all types of DNA damage. In human cells, this task is accomplished by DNA ligases encoded by three genes, LIG1, LIG3 and LIG4. Mutations in LIG1 and LIG4 have been identified as the causative factor in two inherited immunodeficiency syndromes. Moreover, there is emerging evidence that DNA ligases may be good targets for the development of novel anti-cancer agents. In this graphical review, we provide an overview of the roles of the DNA ligases encoded by the three human LIG genes in DNA replication and repair.
摘要
为了确保基因组的完整性，在 DNA 复制过程中以及完成几乎所有类型的 DNA 损伤修复时，都需要将双链 DNA 磷酸二酯骨架上的断裂连接起来。在人类细胞中，这项任务是由三个基因（LIG1、LIG3 和 LIG4）编码的 DNA 连接酶完成的。LIG1 和 LIG4 的突变已被确定为两种遗传性免疫缺陷综合征的致病因素。此外，有新的证据表明，DNA 连接酶可能是开发新型抗癌药物的良好靶点。在这篇图文综述中，我们概述了三个人类 LIG 基因编码的 DNA 连接酶在 DNA 复制和修复中的作用。
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