Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA.
Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA.
DNA Repair (Amst). 2020 Sep;93:102914. doi: 10.1016/j.dnarep.2020.102914.
With the publication of the first paper describing the biochemical properties of DNA polymerase iota (polɩ), the question immediately arose as to why cells harbor such a low-fidelity enzyme which often violates the Watson-Crick base pairing rules? Yet 20 years after its discovery, the cellular function of polɩ remains unknown. Here, we provide a graphical review of the unique biochemical properties of polɩ and speculate about the cellular pathways in which enigmatic polɩ may participate.
随着第一篇描述 DNA 聚合酶iota（polɩ）生化特性的论文发表，人们立即提出了这样一个问题：为什么细胞中存在这种低保真度的酶，它经常违反沃森-克里克碱基配对规则？然而，在它被发现 20 年后，polɩ 的细胞功能仍然未知。在这里，我们提供了一个关于 polɩ 独特生化特性的图形化综述，并推测了神秘的 polɩ 可能参与的细胞途径。
