Department of Neurology, Oita University, Japan.
Intern Med. 2021 Mar 15;60(6):941-944. doi: 10.2169/internalmedicine.5743-20. Epub 2020 Oct 21.
We herein report a patient with neuronal intranuclear inclusion disease (NIID) who presented with encephalitis-like episodes. A neurological examination revealed a disturbance of consciousness without any evidence of encephalitis or epilepsy on laboratory tests. Brain perfusion single-photon emission computed tomography revealed an elevated cerebral blood flow during the encephalitis-like episode and reduced cerebral blood flow in the chronic phase with clinical recovery. This report suggests that the cerebral blood flow of patients with NIID can change over the clinical course. Encephalitis-like episodes of NIID should thus be considered in the differential diagnosis of acute disturbance of consciousness.
我们在此报告一例以脑炎样发作为表现的神经元核内包涵体病（NIID）患者。神经系统检查显示意识障碍，实验室检查无脑炎或癫痫证据。脑灌注单光子发射计算机断层扫描显示脑炎样发作时脑血流升高，临床缓解后慢性期脑血流降低。本报告提示 NIID 患者的脑血流可随临床病程而变化。因此，对于急性意识障碍的鉴别诊断应考虑 NIID 的脑炎样发作。
