Mukherjee Anupama, Spadigam Anita, Dhupar Anita
Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India.
Int J Appl Basic Med Res. 2020 Jul-Sep;10(3):215-217. doi: 10.4103/ijabmr.IJABMR_222_19. Epub 2020 Jul 11.
Oral submucous fibrosis (OSMF) is a potentially malignant disorder, characterized by alteration in the connective tissue stroma. Its association with oral squamous cell carcinoma (OSCC) has been recognized and conferred a special status as a distinct disease entity with improved prognosis as compared to conventional squamous cell carcinoma. Such cases of concomitant presentation of OSMF and OSCC have not yet been defined, leading to ambiguity regarding the evaluation. The concomitant occurrence of OSMF-OSCC is associated with histopathological features, unlike OSMF, yet similar to an aggressive presentation of OSCC. An indepth evaluation of the connective tissue, along with other tumor characteristics such as tissue hypoxia, inflammatory cell population, neoangiogenesis, and stromal cells fortify the possibility of these cases of concomitance being as aggressive, if not more, as compared to conventional OSCC. Thus, recognizing such cases along with the evaluation of probable prognostic indicators is necessary to improve the current understanding of tumorigenesis and progression in concomitant cases of OSMF-OSCC.
口腔黏膜下纤维化（OSMF）是一种潜在的恶性疾病，其特征是结缔组织基质发生改变。它与口腔鳞状细胞癌（OSCC）的关联已得到认可，并作为一种独特的疾病实体被赋予特殊地位，与传统鳞状细胞癌相比，其预后有所改善。OSMF和OSCC同时出现的此类病例尚未得到明确界定，导致评估存在模糊性。OSMF-OSCC的同时发生与组织病理学特征相关，与OSMF不同，但与OSCC的侵袭性表现相似。对结缔组织以及其他肿瘤特征（如组织缺氧、炎症细胞群体、新生血管形成和基质细胞）进行深入评估，强化了这些同时出现的病例与传统OSCC相比即便没有更具侵袭性至少也同样具有侵袭性的可能性。因此，识别此类病例并评估可能的预后指标对于增进目前对OSMF-OSCC同时出现病例中肿瘤发生和进展的理解是必要的。
