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因自残故意注射琥珀酰胆碱后的存活情况。

Survival following intentional succinylcholine injection for self-harm.

作者信息

Kunhahamed Meenhas Oravil, Thomas Vimal Koshy, Abraham Siju Varghese, Palatty Babu Urumese, Kallivalappil Shibu C

机构信息

Department of Emergency Medicine, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.

Department of Anaesthesiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.

出版信息

Turk J Emerg Med. 2020 Oct 7;20(4):193-195. doi: 10.4103/2452-2473.297468. eCollection 2020 Oct-Dec.

DOI:10.4103/2452-2473.297468
PMID:33089028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7549520/
Abstract

Succinylcholine is a short-acting depolarizing neuromuscular blocking agent. We describe a case where the above drug was employed for self-harm by a health-care worker. The patient, a 28-year-old female, was brought to the emergency department (ED) in impending respiratory arrest and altered mental status. On arrival, she had hypoxia, bradycardia, and hypotension. Although the cause for rapid deterioration in this patient was unknown, the ED physician still went ahead by resuscitating the patient's airway, breathing, and circulation. During the course of resuscitation, information was received that an empty ampoule of succinylcholine was recovered from her bathroom. Further clinical examination and laboratory investigations led the treating physicians to suspect deliberate intravenous injection of succinylcholine. She was mechanically ventilated and monitored in the critical care unit. Targeted temperature management was initiated in the ED and was continued for 24 h. The patient was discharged from the hospital without any neurological deficits after 4 days. Patients with acute poisoning are one of the major encounters in ED, and this case highlights the possibility of anesthetic drug misuse in any health-care workers coming to the ED with sudden cardiac arrest, altered sensorium, or abnormal vitals. This is the first report describing the survival of a patient following intentional succinylcholine injection for self-harm.

摘要

琥珀酰胆碱是一种短效去极化型神经肌肉阻滞剂。我们描述了一例医护人员使用上述药物进行自残的病例。该患者为一名28岁女性,被送往急诊科时已处于即将呼吸骤停且意识状态改变的状态。到达时,她存在缺氧、心动过缓和低血压。尽管该患者病情迅速恶化的原因不明,但急诊科医生仍对患者的气道、呼吸和循环进行了复苏。在复苏过程中,得知从她的浴室中发现了一个空的琥珀酰胆碱安瓿。进一步的临床检查和实验室检查使主治医生怀疑患者故意静脉注射了琥珀酰胆碱。她在重症监护病房接受机械通气和监测。在急诊科开始了目标温度管理,并持续了24小时。4天后,患者出院,无任何神经功能缺损。急性中毒患者是急诊科的主要接诊对象之一,该病例凸显了任何因突发心脏骤停、意识改变或生命体征异常前来急诊科的医护人员存在麻醉药物滥用的可能性。这是第一例描述患者故意注射琥珀酰胆碱进行自残后存活的报告。

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Survival following intentional succinylcholine injection for self-harm.因自残故意注射琥珀酰胆碱后的存活情况。
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A fully validated isotope dilution HPLC-MS/MS method for the simultaneous determination of succinylcholine and succinylmonocholine in serum and urine samples.一种经过充分验证的同位素稀释高效液相色谱-串联质谱法,用于同时测定血清和尿液样本中的琥珀酰胆碱和琥珀酰单胆碱。
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