Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow-226031, U.P., India.
Org Biomol Chem. 2020 Nov 4;18(42):8716-8723. doi: 10.1039/d0ob01700k.
A Au(i)-catalyzed homo- and cross-annulation reaction of alkynyl carboxylic acids offering 3,6-disubstituted 4-hydroxy 2H-pyrones has been demonstrated. The reaction tolerates various substituted alkynyl carboxylic acids and moderate to good yields of α-pyrone scaffolds have been observed. Later, a gram-scale reaction of the acid and the total synthesis of the natural product pseudopyronine A have been carried out successfully.
Au(i)催化的炔基羧酸的同环和交叉环化反应，提供了 3,6-二取代的 4-羟基 2H-吡喃酮。该反应可以容忍各种取代的炔基羧酸，并观察到α-吡喃酮支架的中等至良好收率。后来，成功地进行了酸的克级反应和天然产物伪吡喃酮 A 的全合成。
