Angiology and Vascular Surgery Department, 16503Hospital Universitario de Getafe, Madrid, Spain.
Getafe Health Research Institute, Madrid, Spain.
Angiology. 2021 Mar;72(3):260-267. doi: 10.1177/0003319720965419. Epub 2020 Oct 22.
Carotid plaque inflammation assessed by 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) and lipoprotein-associated phospholipase A2 (Lp-PLA) levels are higher in symptomatic patients. The aim of this study was to assess correlations between F-FDG uptake on PET scan of carotid artery plaques, plasma levels of Lp-PLA, and cerebrovascular symptoms. The study included 45 consecutive patients (22 symptomatic, 23 asymptomatic) with >70% carotid stenosis. Patients were examined by hybrid PET/CT, and maximum standardized uptake values (SUV) were recorded. Blood samples were obtained, and plasma was stored at -80 °C for subsequent Lp-PLA analysis. Symptomatic and asymptomatic patients showed no significant difference in classical cardiovascular risk factors. Asymptomatic carotid stenosis patients more frequently had a history of coronary artery disease ( = .025) and peripheral artery disease ( = .012). The symptomatic group had higher F-FDG uptake in carotid plaques ( < .001), higher plasma Lp-PLA ( < .01), and higher high-sensitive C-reactive protein ( = .022). 2-Deoxy-2-[F]fluoro-D-glucose uptake on PET/CT and plasma Lp-PLA show a statistically significant association with the symptomatic status of carotid plaques.
颈动脉斑块炎症通过 2-脱氧-2-[F]氟-D-葡萄糖（F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）和脂蛋白相关磷脂酶 A2（Lp-PLA）水平评估，在有症状的患者中更高。本研究的目的是评估颈动脉斑块 PET 扫描中的 F-FDG 摄取、血浆 Lp-PLA 水平与脑血管症状之间的相关性。该研究纳入了 45 例连续患者（22 例有症状，23 例无症状），颈动脉狭窄>70%。患者接受了混合 PET/CT 检查，并记录了最大标准化摄取值（SUV）。采集血样，并将血浆储存在-80°C，以备后续进行 Lp-PLA 分析。有症状和无症状患者的经典心血管危险因素无显著差异。无症状颈动脉狭窄患者更常患有冠心病（ =.025）和外周动脉疾病（ =.012）。有症状组颈动脉斑块的 F-FDG 摄取更高（ <.001），血浆 Lp-PLA 更高（ <.01），高敏 C 反应蛋白更高（ =.022）。PET/CT 上的 2-脱氧-2-[F]氟-D-葡萄糖摄取和血浆 Lp-PLA 与颈动脉斑块的症状状态具有统计学显著关联。
