Khosla Jagjit, Golamari Reshma, Cai Alice, Benson Jamal, Aronow Wilbert S, Jain Rahul, Jain Rohit
Department of Internal Medicine, Westchester Medical Center, Valhalla, New York, NY 10595, USA.
Penn State Health Milton S Hershey Medical Center, Hershey, PA 17033, USA.
Future Cardiol. 2021 Jul;17(4):693-703. doi: 10.2217/fca-2020-0127. Epub 2020 Oct 22.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disorder resulting in fibrofatty replacement of the myocardium. Genetic mutations in genes encoding for desmosome proteins result in a ventricular myocardium prone to arrhythmias and heart failure. Although ARVC is known for a few decades, most of the outcomes in pregnancy are reported recently. Pregnancy leads to significant physiological changes with excess mechanical stress on the myocardium. All the retrospective studies suggest that pregnancy is well tolerated in these patients despite the high risk of arrhythmias and heart failure. Our review focuses on the most up-to-date evidence on the management of ARVC patients during the antepartum and postpartum period.
致心律失常性右室心肌病（ARVC）是一种遗传性疾病，可导致心肌纤维脂肪替代。编码桥粒蛋白的基因突变会导致心室心肌易于发生心律失常和心力衰竭。尽管ARVC已被知晓数十年，但大多数妊娠结局是最近才报道的。妊娠会导致显著的生理变化，给心肌带来过度的机械应力。所有回顾性研究均表明，尽管这些患者发生心律失常和心力衰竭的风险很高，但妊娠耐受性良好。我们的综述聚焦于ARVC患者产前和产后管理的最新证据。
