Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.
Hospital for Skin Disease, Institute of Dermatology, Chinese Academic of Medical Science, Nanjing, China.
Mycoses. 2020 Nov;63(11):1235-1243. doi: 10.1111/myc.13168. Epub 2020 Sep 9.
In China, the prevalence of superficial fungal infections of the foot is high and recurrence is common. However, a prospective, large-scale and multicentre study on the aetiology of superficial fungal infections of the foot is still lacking.
To study the epidemiology of aetiological agents of superficial fungal infections of the foot in urban outpatients in mainland China, as well as to understand the aetiology features of the pathogenic agent.
The study was designed as a multicentre, prospective epidemiological survey. A total of 1704 subjects were enrolled from seven geographical areas in mainland China. For each subject, one mycological sample and one bacterial sample were collected. KOH wet mount examination and culture were performed at local laboratories. The bacterial results were only reported in those with positive mycology. Further morphological identification and, if necessary, molecular biological identification were conducted in a central laboratory.
Of 1704 enrolled subjects, 1327 (77.9%) subjects had positive fungal culture results. The incidence of dermatophytes, yeasts and moulds was 90.1%, 8.1% and 1.1%, respectively. The most frequently isolated aetiological agent (fungus) was Trichophyton rubrum. Moccasin form was the most commonly reported clinical diagnosis of superficial fungal infections. The most frequently isolated bacterial genus in patients was Staphylococcus.
This study prospectively investigated the clinical and mycological features of human dermatophytosis in mainland China. T rubrum was the most frequently isolated fungus, and moccasin form was the most commonly reported clinical diagnosis of superficial fungal infections.
在中国，足部浅表真菌感染的患病率较高，且易复发。然而，目前仍缺乏针对足部浅表真菌感染病因的前瞻性、大规模、多中心研究。
研究中国城市门诊患者足部浅表真菌感染的病原体流行病学，了解致病病原体的病因特征。
本研究设计为多中心、前瞻性的流行病学调查。共从中国大陆 7 个地理区域招募了 1704 名受试者。每位受试者采集 1 份真菌学样本和 1 份细菌样本。在当地实验室进行 KOH 湿片检查和培养。仅在真菌学阳性的情况下报告细菌结果。在中央实验室进行进一步的形态学鉴定，如果必要，还进行分子生物学鉴定。
在 1704 名入组受试者中，1327 名（77.9%）受试者的真菌培养结果为阳性。皮肤癣菌、酵母菌和霉菌的发病率分别为 90.1%、8.1%和 1.1%。最常分离到的病原体（真菌）是红色毛癣菌。蕈样足是报告的最常见的浅表真菌感染临床诊断。患者中最常分离到的细菌属是葡萄球菌属。
本研究前瞻性地调查了中国大陆人群的人皮肤癣菌病的临床和真菌学特征。T rubrum 是最常分离到的真菌，蕈样足是报告的最常见的浅表真菌感染临床诊断。
