Malov G A, Petrosian Iu S, Vishchipanov S A, Cherniavskaia Z V
Kardiologiia. 1977 Jun;17(6):23-30.
The clearance of intracoronarily introduced 133Xe was employed in investigating the myocardial blood flow in 105 patients, 10 of whom--controls and 95 suffering from various manifestations of ischemic heart disease. Use was made of the biexponential calculation of the clearance curve by taking account of the fast (circulation in normal tissues) and slow exponent (circulation along the cicatricially-altered sections of the myocardium) contributions to the common "effective" myocardial blood flow. In patients with ischemic heart disease a reduction of the myocardial blood flow depending upon the severity of the clinical picture and the degree of the coronary arteries lesion was revealed. A direct correlational dependence between the initial state of the myocardial circulation at rest and the level of the physical efforts tolerance was educed. A conclusion is drawn that the determination of the myocardial circulation by the method of the 133Xe clearance following intracoronarily administration of the substance should be done by taking account of the slow and fast exponents of the clearance curve, these exponents reflecting the circulation in sections of the myocardium differing in their functional activity.
采用冠状动脉内注入133Xe的清除率来研究105例患者的心肌血流，其中10例为对照组，95例患有缺血性心脏病的各种表现。通过考虑清除曲线的双指数计算来利用快速（正常组织中的循环）和慢速指数（沿心肌瘢痕改变区域的循环）对共同的“有效”心肌血流的贡献。在缺血性心脏病患者中，发现心肌血流根据临床表现的严重程度和冠状动脉病变程度而降低。得出了静息时心肌循环的初始状态与体力耐受水平之间的直接相关依赖性。得出结论，冠状动脉内给予该物质后，通过133Xe清除率方法测定心肌循环时，应考虑清除曲线的慢速和快速指数，这些指数反映了心肌不同功能活动区域的循环情况。
