Sawada T
Department of Animal Reproduction, College of Agriculture, University of Osaka Prefecture, Japan.
J Reprod Fertil. 1987 Jul;80(2):595-8. doi: 10.1530/jrf.0.0800595.
Attempts were made to induce pregnancy in androgen-treated immature rats. Treatment with PMSG alone, which causes ovulation in normal immature rats, failed to cause ovulation in androgenized rats. However, treatment with PMSG plus LHRH was effective in causing ovulation. After ovulation, some of the normal and androgenized rats mated. Normal mated rats became pregnant but androgenized mated rats did not. However, when a pituitary gland was transplanted from a normal rat into the kidney capsule of an androgenized rat to maintain functional corpora lutea, implantation occurred in some of the mated animals. The positive decidual reaction in the uteri of such androgenized rats was similar to that observed in normal rats. These results suggest that the uterine sensitivity to blastocyst implantation of androgenized immature rats may be normal.
人们尝试在经雄激素处理的未成熟大鼠中诱导怀孕。单独使用促卵泡素（PMSG）进行处理，这会使正常未成熟大鼠排卵，但在雄激素化的大鼠中未能引起排卵。然而，用促卵泡素（PMSG）加促黄体生成素释放激素（LHRH）进行处理可有效引起排卵。排卵后，一些正常和雄激素化的大鼠进行了交配。正常交配的大鼠怀孕了，但雄激素化交配的大鼠没有。然而，当将一只正常大鼠的垂体移植到一只雄激素化大鼠的肾包膜中以维持功能性黄体时，一些交配的动物发生了着床。这种雄激素化大鼠子宫中的阳性蜕膜反应与正常大鼠中观察到的相似。这些结果表明，雄激素化未成熟大鼠子宫对胚泡着床的敏感性可能是正常的。
