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伴发于融合阳性局限性附睾肺泡横纹肌肉瘤的副肿瘤性视神经炎患儿。

Para-neoplastic optic neuritis presenting in a child with fusion positive localised para-testicular alveolar rhabdomyosarcoma.

机构信息

Department of Pediatrics, Royal Aberdeen Children's Hospital, Aberdeen, UK.

Department of Pediatric Hematology & Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

出版信息

Pediatr Hematol Oncol. 2021 May;38(4):397-402. doi: 10.1080/08880018.2020.1836100. Epub 2020 Oct 23.

Abstract

We present the case of a 13 year old boy, with sudden onset painful unilateral visual loss, prior to commencing chemotherapy for alveolar rhabdomyosarcoma. Cases of para-neoplastic optic neuritis have been reported in adult cancer patients, however there are no published reports of this phenomenon occurring in children. Our patient had full recovery of his vision, following 6 weeks treatment with steroids, immunoglobulins and standard chemotherapy as per high risk arm of European pediatric soft tissue sarcoma group (EpSSG) Rhabdomyosarcoma (RMS) 2005 guidelines. Our case highlights that para-neoplastic optic neuritis can occur in children. In pediatric patients presenting with optic neuritis and normal auto-antibody screen, an occult or underlying tumor should be considered.

摘要

我们报告了一例 13 岁男孩的病例,他在开始化疗治疗肺泡横纹肌肉瘤之前突然出现单侧视力丧失伴疼痛。已经有报道称成人癌症患者出现副肿瘤性视神经炎,但目前尚无文献报道这种现象发生在儿童中。我们的患者在接受 6 周的类固醇、免疫球蛋白和标准化疗治疗后,视力完全恢复,这符合欧洲儿科软组织肉瘤组(EpSSG)横纹肌肉瘤(RMS)2005 指南的高危组治疗方案。我们的病例强调了副肿瘤性视神经炎可发生在儿童中。在出现视神经炎且自身抗体筛查正常的儿科患者中,应考虑存在隐匿性或潜在肿瘤。

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