Estrem S A, Domayer M, Bardach J, Cram A E
Division of Otolaryngology, Head and Neck Surgery, University of Missouri-Columbia.
Laryngoscope. 1987 Oct;97(10):1214-8. doi: 10.1288/00005537-198710000-00018.
In the interest of developing an animal model for keloids, human keloid dermis was implanted in the subcutaneous tissues of athymic (nude) mice. Subsequent growth resulted in a lesion with histology similar to the original keloid. Fibroblasts were cultured from keloid dermis. When the fibroblasts alone were implanted in the subcutaneous tissues of nude mice, growth of a visible lesion was again produced. The fibroblasts had proliferated and deposited collagen in an abnormal fashion with the histology resembling the parent keloid. Further research could develop this into a reliable animal model to allow in vivo experimentation.
为了开发瘢痕疙瘩的动物模型，将人瘢痕疙瘩真皮植入无胸腺（裸）小鼠的皮下组织。随后的生长导致了一个组织学上与原始瘢痕疙瘩相似的病变。从瘢痕疙瘩真皮中培养成纤维细胞。当仅将成纤维细胞植入裸鼠的皮下组织时，再次产生了可见病变的生长。成纤维细胞以异常方式增殖并沉积胶原蛋白，其组织学类似于母本瘢痕疙瘩。进一步的研究可以将其发展成为一个可靠的动物模型，以进行体内实验。
