Burton H W, Faulkner J A
Department of Physiology, University of Michigan Medical School, Ann Arbor 48109.
Microvasc Res. 1987 Jul;34(1):59-68. doi: 10.1016/0026-2862(87)90079-3.
Arteriolar responses to the vasodilator adenosine and to the vasoconstrictor norepinephrine (NE) were examined in small bundles of extensor digitorum longus muscle grafted onto the cheek pouches of hamsters. Responses of arterioles to topically applied adenosine or NE were measured from 30 to 180 days after grafting and compared with the response of arterioles in control cheek pouches. Verapamil and potassium chloride (KCl) were applied to 120- and 180-day grafts to determine the response of arterioles to vasoactive agents not mediated by receptors. Arterioles in grafted muscle did not respond to adenosine until 60 days. The response increased with time but was significantly less than the control value even after 180 days. Arterioles in grafts did not respond to NE until 90 days. At both 90 and 120 days the degree of constriction in response to NE was not uniform along the length of a given arteriole (punctate response). By 180 days, the response of a given arteriole to NE was uniform but significantly less than the control value. In 120- and 180-day grafts the responses of arterioles to verapamil and KCl were similar to the responses of arterioles to adenosine and NE, respectively. We conclude that the diminished response of arterioles in small EDL muscle grafts to vasoactive agents may be caused by either a structural or a functional impairment in the smooth muscle layer of arterioles.
在移植到仓鼠颊囊上的一小束趾长伸肌中，研究了小动脉对血管舒张剂腺苷和血管收缩剂去甲肾上腺素（NE）的反应。在移植后30至180天测量小动脉对局部应用的腺苷或NE的反应，并与对照颊囊中动脉的反应进行比较。将维拉帕米和氯化钾（KCl）应用于120天和180天的移植物，以确定小动脉对非受体介导的血管活性药物的反应。移植肌肉中的小动脉直到60天才对腺苷产生反应。反应随时间增加，但即使在180天后仍显著低于对照值。移植组织中的小动脉直到90天才对NE产生反应。在90天和120天时，给定小动脉对NE的收缩程度在其长度上并不均匀（点状反应）。到180天时，给定小动脉对NE的反应是均匀的，但显著低于对照值。在120天和180天的移植物中，小动脉对维拉帕米和KCl的反应分别类似于小动脉对腺苷和NE的反应。我们得出结论，小趾长伸肌移植物中小动脉对血管活性药物反应减弱可能是由于小动脉平滑肌层的结构或功能损伤所致。
