Stolecke H
Klinik für Kinder- und Jugendmedizin, Universitätsklinikum der Gesamthochschule Essen.
Monatsschr Kinderheilkd. 1987 Aug;135(8):474-8.
Some important aspects of current knowledge on female pubertal development are reviewed specially regarding hormonal events. Pulsatile hypothalamic (LHRH-) activity occurs early in childhood and shows a specific development after the onset of puberty, resulting in progressive enhancement of gonadal estrogen and gestagen secretion finally until the menstrual cycle is established by specially characterized hormonal controls. In the ovary an "internal metabolic milieu" is necessary for normal adult function. Some pathophysiological problems and clinical syndromes leading to functional or systemic developmental failure are discussed shortly.
本文特别就激素变化对当前女性青春期发育的一些重要知识进行了综述。下丘脑促黄体生成素释放激素（LHRH）的脉冲式活动在儿童早期就已出现，并在青春期开始后呈现出特定的发展变化，最终导致性腺雌激素和孕激素分泌逐渐增加，直至通过特定的激素调控建立月经周期。在卵巢中，“内部代谢环境”是成年后正常功能所必需的。本文简要讨论了一些导致功能或全身发育障碍的病理生理问题和临床综合征。
