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[神经细胞分化过程中的细胞骨架]

[The cytoskeleton of nerve cells during their differentiation].

作者信息

Skibo G G, Berezovskaia O L

出版信息

Neirofiziologiia. 1987;19(4):558-67.

PMID:3309686
Abstract

Ultrastructural and cytochemical characteristics of cytoskeletal elements of the cell (microtubules, microfilaments and neurofilaments), their state and proportion in a mature neuron and at definite stages of its differentiation are analyzed. Structural and functional properties of microtubule-associated proteins are described with their distribution in different parts of the neuron and quantitative changes in the course of differentiation. Data from literature concerning functional significance of cytoskeletal elements of the neuron, their connections with electrically excitable surface membrane and participation of the cytoskeleton in pathological states of the nervous system are discussed.

摘要

分析了细胞骨架成分(微管、微丝和神经丝)的超微结构和细胞化学特征,及其在成熟神经元及其分化特定阶段的状态和比例。描述了微管相关蛋白的结构和功能特性,以及它们在神经元不同部位的分布和分化过程中的定量变化。讨论了来自文献的关于神经元细胞骨架成分的功能意义、它们与电兴奋性表面膜的联系以及细胞骨架在神经系统病理状态中的参与情况的数据。

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