Klintmalm G
Department of Surgery, Baylor University Medical Center, Dallas.
Nephrologie. 1987;8(3):131-3.
Treatment with cyclosporine in renal transplantation causes an increased incidence of interstitial fibrosis. The degree of interstitial fibrosis seems to be correlated with high cyclosporine consumption and episodes of acute CyA nephrotoxicity. The cause of acute CyA nephrotoxicity seems to be hemodynamic alterations. Whether this is the cause for the chronic nephrotoxicity has still not been shown.
肾移植中使用环孢素治疗会导致间质纤维化的发生率增加。间质纤维化的程度似乎与高剂量环孢素的使用以及急性环孢素肾毒性发作有关。急性环孢素肾毒性的原因似乎是血流动力学改变。但这是否是慢性肾毒性的原因仍未得到证实。
