Curr Probl Cardiol. 2021 Mar;46(3):100718. doi: 10.1016/j.cpcardiol.2020.100718. Epub 2020 Sep 25.
Omega-3-fatty-acids are now increasingly being used for potential beneficial anti-inflammatory effect in the treatment and management of cardiovascular disease. Eicosapentaenoic acid and Docosahexaenoic acid are 2 essential omega-3 fatty acids found predominately in fish and fish oil supplements. Despite the increased use of fish oil products for both primary and secondary prevention of cardiovascular morbidity and mortality, the available literature evidence are controversial. We searched through PubMed for studies that have investigated the impact of omega-3 fatty acids on coronary heart disease and mortality. Our systemic review suggests that most studies, which are mostly observational, have found there to be a potential benefit of omega-3 fatty acids on coronary heart disease whereas some other studies have found conflicting results. More randomized controlled studies are warranted with adequate sample size to clearly establish the risk and benefits of omega-3 fatty acids on cardiovascular disease.
ω-3 脂肪酸现在越来越多地被用于治疗和管理心血管疾病的潜在抗炎作用。二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）是两种主要的 ω-3 脂肪酸，主要存在于鱼类和鱼油补充剂中。尽管鱼油产品在心血管疾病发病率和死亡率的一级和二级预防中的使用有所增加，但现有文献证据存在争议。我们在 PubMed 上搜索了研究 ω-3 脂肪酸对冠心病和死亡率影响的研究。我们的系统评价表明，大多数研究（主要是观察性研究）发现 ω-3 脂肪酸对冠心病有潜在益处，而其他一些研究则得出了相互矛盾的结果。需要更多的随机对照研究，并具有足够的样本量，以明确确定 ω-3 脂肪酸对心血管疾病的风险和益处。
