超高龄（≥89 岁）老年乳腺癌患者：肿瘤特征、治疗选择、临床结局及文献复习。
Breast cancer in the oldest old (≥ 89 years): Tumor characteristics, treatment choices, clinical outcomes and literature review.
机构信息
Oncology Institute of Southern Switzerland - IOSI, Bellinzona, Switzerland; CSSI, Centro di Senologia Della Svizzera Italiana, Ente Ospedaliero Cantonale - EOC, Switzerland.
Gynecology and Obstetric Department, Ente Ospedaliero Cantonale - EOC, Lugano, Switzerland.
出版信息
Eur J Surg Oncol. 2021 Apr;47(4):796-803. doi: 10.1016/j.ejso.2020.10.008. Epub 2020 Oct 13.
INTRODUCTION
Risk of breast cancer increases with age and very few data are available in patients older than 89.
METHODS
A retrospective analysis on patients aged 89 and older treated between 2008 and 2019 at our certified breast center. The aim was to analyze clinical characteristics, decision-making, treatment, outcomes and open questions regarding this subpopulation for which there is a lack of guidelines.
RESULTS
58 patients included. Tumor characteristics were analyzed, 85% patients underwent surgery of which 44% had a mastectomy. The median follow-up and overall survival were 20 and 76 months, respectively.The median survival of metastatic and non-metastatic patients were 14 and 50 months, respectively. Most patients did not receive any adjuvant treatment and among these 14% had a relapse.
CONCLUSIONS
Elderly patients should not be under or over-treated because of their age; they represent a large heterogeneous group deserving a sub-stratification for a better tailored treatment.
简介
乳腺癌的风险随着年龄的增长而增加，而 89 岁以上患者的数据非常有限。
方法
对 2008 年至 2019 年在我们认证的乳腺中心治疗的 89 岁及以上患者进行回顾性分析。目的是分析该亚组人群的临床特征、决策、治疗、结果和存在的问题，因为针对该人群缺乏指南。
结果
共纳入 58 例患者。分析了肿瘤特征，85%的患者接受了手术，其中 44%的患者进行了乳房切除术。中位随访和总生存时间分别为 20 个月和 76 个月。转移性和非转移性患者的中位生存时间分别为 14 个月和 50 个月。大多数患者未接受任何辅助治疗，其中 14%的患者出现复发。
结论
不应因年龄而对老年患者过度治疗或治疗不足；他们代表着一个庞大的异质性群体，需要进行亚分层，以获得更个性化的治疗。
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