Cardiology Department, Zagazig University, Zagazig, Egypt; Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy.
Cardiology Department, Zagazig University, Zagazig, Egypt.
Cardiovasc Revasc Med. 2021 Apr;25:63-71. doi: 10.1016/j.carrev.2020.10.003. Epub 2020 Oct 16.
Vulnerable plaques are the primary cause of acute coronary syndrome (ACS). The association between in-vivo plaque vulnerability and adiponectin levels in ACS still remains to be determined.
The purpose of this study was to investigate the correlation between adiponectin levels and vulnerable plaque features in ACS patients.
We enrolled 107 ACS patients admitted to our institution; 83 with Non-ST elevation ACS (NSTE-ACS) and 24 with ST-elevation myocardial infarction (STEMI). Adiponectin levels were measured in these patients. Coronary angiography and subsequent optical coherence tomography (OCT) analysis of culprit lesions were performed.
Adiponectin level was lower in patients with complex angiographic lesions, compared to those with non-complex lesions (7.13 ± 3.04 vs. 8.94 ± 2.84 μg/ml, P = 0.002). Adiponectin level was lower in patients with plaque rupture (PR), micro-thrombi, and thin cap fibroatheroma (TCFA), compared to those with non-vulnerable features (7.19 ± 2.95 vs 8.79 ± 3.02 μg/ml, P = 0.007 & 7.29 ± 2.97 vs 8.44 ± 3.09 μg/ml, P = 0.04 and 4.76 ± 0.65 vs 9.74 ± 2.35 μg/ml, P < 0.001 μg/ml respectively). There was a significant negative correlation between adiponectin levels and lipid rich plaque extent and maximum lipid arc (r = -0.05, P < 0.001 & r = -0.03, P = 0.03, respectively). However, a significant positive correlation was observed between adiponectin levels and fibrous cap thickness (r = 0.95, P < 0.001).
Low adiponectin levels were associated with complex angiographic lesions and vulnerable plaque features in ACS patients, where there was a significant correlation between it and PR, TCFA, and lipid rich plaque.
易损斑块是急性冠脉综合征（ACS）的主要病因。ACS 患者体内斑块易损性与脂联素水平之间的关系仍有待确定。
本研究旨在探讨 ACS 患者脂联素水平与易损斑块特征之间的相关性。
我们纳入了我院收治的 107 例 ACS 患者，其中 83 例为非 ST 段抬高型 ACS（NSTE-ACS），24 例为 ST 段抬高型心肌梗死（STEMI）。测量这些患者的脂联素水平。对罪犯病变进行冠状动脉造影和随后的光学相干断层扫描（OCT）分析。
与非复杂病变患者相比，复杂血管造影病变患者的脂联素水平较低（7.13±3.04 比 8.94±2.84μg/ml，P=0.002）。与非易损特征患者相比，斑块破裂（PR）、微血栓和薄帽纤维粥样瘤（TCFA）患者的脂联素水平较低（7.19±2.95 比 8.79±3.02μg/ml，P=0.007 和 7.29±2.97 比 8.44±3.09μg/ml，P=0.04 和 4.76±0.65 比 9.74±2.35μg/ml，P<0.001）。脂联素水平与富含脂质斑块的程度和最大脂质弧呈显著负相关（r=-0.05，P<0.001 和 r=-0.03，P=0.03）。然而，脂联素水平与纤维帽厚度呈显著正相关（r=0.95，P<0.001）。
ACS 患者的脂联素水平与复杂血管造影病变和易损斑块特征相关，与 PR、TCFA 和富含脂质斑块之间存在显著相关性。
